Intra-cellular Therapies, Inc.

Joseph Hendrick

Lawrence P Wennogle

Gretchen Snyder

Peng Li

Hailin Zheng

Jennifer O'Brien

Robert E Davis

David Kass

Toru Hashimoto

The disclosure relates to the use of phosphodiesterase 1 (PDE1) inhibitors for the treatment of cancers and tumors, including for inhibiting tumor recruitment of macrophages and other cells to the tumor or cancer, for complementing and enhancing checkpoint inhibitor therapies, and for mitigating the side effects (i.e., inflammatory-related adverse events) associated with checkpoint inhibitor therapies.

Organic compounds

The disclosure provides methods, treatments and materials for enhancing the effect of an adenosine Areceptor agonist in the treatment, mitigation or prophylaxis of a disease or condition characterized by inotropic and/or lusitropic dysfunction, and/or enhancing adenosine Areceptor function in the treatment, mitigation or prophylaxis of a disease or condition characterized by impaired adenosine Areceptor function, comprising administration of an effective amount of a PDE1 inhibitor to a patient in need thereof, for example a patient suffering from heart failure.

Methods for treating or mitigating cardiotoxicity characterized by inhibition of adenosine Asignaling and/or adenosine Areceptor expression

Uses

The disclosure provides the administration of inhibitors of phosphodiesterase 1 (PDE1) for the treatment and prophylaxis of diseases or disorders characterized by inflammation, e.g., neuroinflammation, including methods of treatment and pharmaceutical compositions for use therein.

The present invention relates to certain PDE2 inhibitory compounds, in free or salt form, pharmaceutical compositions containing such compounds and methods for the treatment of PDE2 mediated disorders.

The present invention relates to a product comprising a PDE1 inhibitor and a PDE2 inhibitor, in free or salt form, pharmaceutical compositions comprising them and their use as pharmaceuticals for the treatment of cAMP and/or cGMP related disorders.

Growing community of inventors

Bridgeport, CT, United States of America

Joseph Hendrick