Schering Corporation

Becton Dickinson and Company Limited

Other

Merck Sharp + Dohme Corp.

Leland Stanford Junior University

Joseph H Phillips

Lewis L Lanier

Alexander B H Bakker

Michael Eric Bigler

Daniel M Gorman

Terrill K McClanahan

Gosse Jan Adema

Holly Cherwinski

Linde Meyaard

Leonard G Presta

Gerard Zurawski

Sandra M Zurawski

Drake LaFace

Eric Anthony

Chiwen Chang

Daniel J Cua

Barbara Joyce-Shaikh

Robert Booher

Peter R Parham

Venkataraman Sriram

Peter Strack

Anne L Jackson

Paul G Heyworth

Douglas C Wilson

Arnon Nagler

Jose Aramburu Beltran

Miguel Lopez-Botet

Jonathon D Sedgwick

Jennifer E Gumperz

Virginia M Litwin

Kalyan Pande

Drake M Laface

Peter Richard Strack

The present disclosure describes combination therapies comprising an antagonist of Programmed Death 1 receptor (PD-1) and the CDK inhibitor dincaciclib, and the use of the combination therapies for the treatment of cancer, and in particular for treating cancers that express PD-L1.

Treating cancer with a combination of a PD-1 antagonist and dinaciclib

The invention provides methods for modulation interactions between MDL-1 and its binding partner, Gal9. Also provided are methods to screen for modulators of MDL-1/Gal9 interaction.

MDL-1 ligand

Provided are methods for modulating activity of the immune system using agonists or antagonists of a CD200 receptor. Also provided are methods of treatment and diagnosis of immune disorders.

Methods of modulating CD200 receptors

The invention relates generally to the field of immunology, in particular, to bispecific antibodies. Methods for designing a bispecific antibody for use in treating diseases relating to the immune system are disclosed. Specific examples relate to bispecific antibodies which recognize an activating receptor and an inhibiting receptor.

Use of bispecific antibodies to regulate immune responses

The present invention relates to binding compounds specific for the human inhibitory CD200R and uses thereof. More specifically, the invention relates to antibodies that recognize the human inhibitory CD200R and modulates its activity in inflammatory and autoimmune disorders.

Antibodies to CD200R

The present invention relates to methods for identifying and using modulators of FDF03 biological activity in vitro and in vivo that are useful in the treatment of cancer.

Methods for inhibiting tumor growth or reducing metastatic burden in a subject by administering FDF03 antibodies

Antibodies to human MDL-1 are provided, as well as uses thereof, e.g., in treatment of immune disorders, in particular, infectious diseases and sepsis.

Anti-MDL-1 antibodies

Nucleic acids encoding various monocyte cell proteins from a primate, reagents related thereto, including specific antibodies, and purified proteins are described. Methods of using reagents and related diagnostic kits are also provided.

Antibodies that bind DNAX leukocyte associated immunoglobulin-like receptor

The purification and isolation of various genes which encode mammalian cell surface polypeptides. Nucleic acids, proteins, antibodies, and other reagents useful in modulating development of cells, e.g., lymphoid and myeloid, are provided, along with methods for their use.

DAP12 nucleic acids

MDL-1 polypeptides

Binding compounds to DAP12 proteins

Antibodies and fragments thereof to MDL-1 protein

An early-warning security system for monitoring and tracking in real-time or at least in near-real-time the activities and movements associated with prescribed personnel, personal property, mobile vehicles, and buildings. The system comprises a plurality of in situ local controllers having a microprocessor and a coordinated plurality of conspicuous and clandestine digital video cameras for continuously producing digital audio and visual signals, uplinking such signals via a suitable wireless telecommunications device to a satellite, general packet radio service, the Internet, intranet or extranet, and then downlinking these signals to a plurality of control centers for recording and analysis thereof. Uplinking of these digital signals may occur continuously or may be activated by a manual or predefined trigger event. Preventive or remedial action is immediately taken when perturbations from normal behavior or activities are observed in the recorded audio and visual signals.

Early warning near-real-time security system

An early-warning security system for monitoring and tracking in real-time the activities and movements associated with prescribed personnel, personal property, mobile vehicles, and buildings. The system comprises a plurality of in situ local controllers having a microprocessor and a coordinated plurality of conspicuous and clandestine digital video cameras for continuously producing digital audio and visual signals, uplinking such signals via a suitable wireless telecommunications device to a satellite, general packet radio service, the Internet, intranet or extranet, and then downlinking these signals to a plurality of control centers for recording and analysis thereof. Uplinking of these digital signals may occur continuously or may be activated by a manual or predefined trigger event. Preventative or remedial action is immediately taken when perturbations from normal behavior or activities are observed in the recorded audio and visual signals.

Early warning real-time security system

Nucleic acids encoding various monocyte cell proteins from a primate, reagents related thereto, including specific antibodies, and purified proteins are described. Methods of using reagents relating to nucleic acids encoding monocyte cell proteins, and diagnostic kits, are also provided.

Antibodies that specifically bind DNAX leukocyte associated immunoglobulin-like receptor

Growing community of inventors

Palo Alto, CA, United States of America

Joseph H Phillips