Ceskoslovenska Akademie Ved

Joseph H Cort

Tomislav Barth

Karel Jost

Zdenek Veznik

Frantisek Sorm

Zdenko Prochazka

The use of long-acting oxytocin analogs, characterized chemically by replacement of the disulfide bridge by a thioether bridge, in safely increasing the milk products in mammals is disclosed. Of particular importance in the use of these compounds is the safety factor, that is, the absence of dangerous side effects at dosage levels required for increasing lactation. An increase in milk production can be accomplished with one or, at most, two single injections.

Method for increasing the milk let down in mammals

The use of long-acting oxytocin analogs, characterized chemically by replacement of the disulfide bridge by a thioether bridge, in safely inducing labor in mammals is disclosed. Of particular importance in the use of these compounds is the safety factor, that is, the absence of uterine tetany, dangerous to both mother and fetus, at dosage levels required for induction of complete labor. Induction of complete labor can be accomplished with one or, at most, two single injections.

Long-acting oxytocin analogs for use in inducing and accelerating labor

Stepwise synthesis in solution and cyclization by means of active esters or another method suitable for peptide bond formation were used to prepare analogues of deamino-vasopressin with the disulphide bridge altered to the thioether group. In sequence position 8 of the peptide chain the analogs differed by the nature of basic amino acid. Typical vasopressin-like activities, mainly antidiuretic, were very high in these analogs; of particular importance will be their haemodynamic activity.

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Prague, Czechia

Joseph H Cort