Technicon Instruments Corporation

Joseph Felix Heremans

Pierre L Masson

Biological fluids, such as serum, are analyzed for the presence, nature and/or amount of antibodies, antigens and antibody:antigen complexes therein using as a reagent, insolubilized rheumatoid factor or insolubilized Clq. These reagents are themselves novel. They bind to antibody:antigen complexes, but not to free antibodies or antigens, and complexes can thus be removed from mixtures thereof with other materials, such as antibodies and antigens.

Analysis of biological fluids

Biological fluids, such as serum, are analyzed for the presence, nature and/or amount of antibodies, antigens and antibody:antigen complexes therein using as a reagent, insolubilized rheumatoid factor or insolubilized C1q. These reagents are themselves novel. They bind to antibody: antigen complexes, but not to free antibodies or antigens, and complexes can thus be removed from mixtures thereof with other materials, such as antibodies and antigens.

Antigen-antibody analysis with solid phase RF and C1q

A method for analyzing a biological fluid sample for Ab, Ag, or Ab:Ag complexes therein which includes the step of adding to the sample a solution of RF or Clq to bind with Ab:Ag complexes present or formed therein, and thereafter analyzing the mixture so formed for complexes bound to RF.

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Leuven, Belgium

Joseph Felix Heremans