Arena Pharmaceuticals, Inc.

Tripos, Inc.

Joseph F Russo

Derek T Chalmers

Chen Wang Liaw

Dominic P Behan

William J Thomsen

Qian Liu

Robert C Glen

Richard J Foster

Michael S Lawless

Julian R Smith

Nigel R Beeley

Disclosed herein are non-endogenous, constitutively activated forms of the human 5-HTand human 5-HTreceptors and uses of such receptors to screen candidate compounds. Further disclosed herein are candidate compounds identified by the screening method which act at the 5HTreceptors. Yet further disclosed is a new class of compounds which act at the 5HTreceptors.

Non-endogenous, constitutively activated human serotonin receptors and small molecule modulators thereof

Disclosed herein are non-endogenous, constitutively activated forms of the human 5-HT and human 5-HT receptors and uses of such receptors to screen candidate compounds. Further disclosed herein are candidate compounds identified by the screening method which act at the 5HT receptors. Yet further disclosed is a new class of compounds which act at the 5HT receptors.

Disclosed herein are non-endogenous, constitutively activated forms of the human 5-HT.sub.2A and human 5-HT.sub.2C receptors and uses of such receptors to screen candidate compounds. Further disclosed herein are candidate compounds identified by the screening method which act at the 5HT.sub.2A receptors. Yet further disclosed is a new class of compounds which act at the 5HT.sub.2A receptors.

Small molecule modulators of non-endogenous, constitutively activated

A compound of formula (C) useful as a serotonin receptor modulator

Non-endogenous, constitutively activated human serotonin receptors and

Disclosed herein is a new class of pyrazole compounds which act at the 5HT.sub.2A receptors.

Growing community of inventors

Murrieta, CA, United States of America

Joseph F Russo