Hoechst Roussel Pharmaceuticals

Merck + Co., Inc.

Amgen Inc.

Hoechst Marion Roussel

Other

Bristol-myers Squibb Compnay

Merck Sharp + Dohme Corp.

Joseph F Payack

Lawrence L Martin

Denise M Flanagan

Helen H Ong

Mark A Huffman

Dongwei Cai

Salvatore M Brucato

Julio Cesar Medina

Matthew W Martin

Jean-Christophe P Harmange

Ryan D White

Thomas R Verhoeven

Alan Martin Allgeier

Jiwen Liu

Dalian Zhao

Philip J Pye

Yingcai Wang

Lushi Tan

Kevin Michael Belyk

An-Rong Li

John Limanto

David L Hughes

Ian Frank Cottrell

Chung-Pin H Chen

Jonathan Clive Tripp

Wendel William Doubleday

Richard J Fox

Mitchell J Schultz

Dayne Dustan Fanfair

Yongli Su

Jay Larrow

Thomas Storz

David Hands

Frederick W Hartner

Jerry A Murry

Mark Grillo

Karel M Jos Brands

Roger Zanon

Jacqueline E Milne

Saravanababu Murugesan

Sabrina E Ivy

Janan Jona

Mahmoud S Kaba

Yohannes Teffera

Raju Subramanian

Mina Dilmeghani Seran

Naoki Yoshikawa

Jacqueline Milne

Enrique Vazquez

Benjamin Dorner

The invention provides a method and apparatus for continuous extraction of plant oils from plant tissue using an advantageous azeotrope of ethanol and water and employing the differing solubility of plant oils in ethanol and water to drive formation of a non-toxic oil tincture.

Method and apparatus for extracting plant oils using ethanol water

A method for making the compound of Formula I: is set forth using alkylation, amidation, chlorination and phosphate installation procedures.

Methods of making HIV attachment inhibitor prodrug compound and intermediates

Compounds, pharmaceutical compositions and methods are provided that are useful in the treatment of inflammatory and immune-related diseases and conditions. In particular, the invention provides compounds which modulate the function and/or expression of proteins involved in atopic diseases, inflammatory conditions and cancer. The subject compounds are carboxylic acid derivatives.

Phenyl acetic acid derivatives

The present invention is concerned with a novel process for the preparation of the compound 5-[[2(R)-[1(R)-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3(S)-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3H-1,2,4 -tria-zol-3-one. This compound is useful as a substance P (neurokinin-1) receptor antagonist. In particular, the compound is useful e.g., in the treatment of psychiatric disorders, inflammatory diseases and emesis.

Process for 5-[[2(r)-[1(r)-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3(s)-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3h-1.,2,4-triazol-3-one

Selected benzomorpholine compounds, including 7-((6,7-bis(methyloxy)-4-quinolinyl)oxy)-N-(5 -methyl-3-isoxazolyl)-2,3-dihydro-4H-1,4-benzoxazine-4-carboxamide, are effective for prophylaxis and treatment of diseases, such as VEGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

Benzomorpholine derivatives and methods of use

The present invention is concerned with novel processes for the preparation of (2R, 2-alpha-R)-4-benzyl-2-&lsqb;1-&lsqb;3,5-bis(trifluoromethyl)phenyl&rsqb;ethoxy-1,4-oxazin-3-one. This compound is useful as an intermediate in the synthesis of compounds which possess pharmacological activity.

Process for the synthesis of (2R, 2-alpha-R)-4-benzyl-2-&lsqb;1-(3,5-bis (trifluoromethyl)phenyl)ethoxy&rsqb;-1,4-oxazine-3-one

The present invention is directed to a process for the preparation of titanocene dichloride (Cp.sub.2 TiCl.sub.2) from the titanocene dimer (Cp.sub.2 TiMe).sub.2 O), which is produced as a by-product from employing the reagent dimethyl titanocene (Cp.sub.2 Ti(CH.sub.3).sub.2) in the methylenation of carbonyl compounds, such as esters and lactones.

Process for the preparation of titanocene dichloride

The present invention is directed to a process for the preparation of the reagent dimethyl titanocene (Cp.sub.2 Ti(CH.sub.3).sub.2) from titanocene dichloride (Cp.sub.2 TiCl.sub.2) and a methyl magnesium halide, in particular, methyl magnesium chloride (CH.sub.3 MgCl). The instant process provides the desired reagent in a manner which is generally less hazardous and more economical than previous methods.

Process for the preparation of dimethyl titanocene

Novel 2-(4-piperidinyl)-1H-pyrido[4,3-b]indol-1-ones and related compounds, intermediates and processes for the preparation thereof, and methods of treating psychoses employing compounds and compositions thereof are disclosed.

2-(4-piperidinyl)-1H-pyrido[4,3-b]indol-1-ones and related compounds

Novel 4,5-dihydro-4-heteroaryl-3H-1,3-benzodiazepines, intermediates, processes for the preparation thereof, and methods for treating depression, inhibiting convulsions and treating anxiety utilizing compounds and compositions thereof are disclosed.

4-heteroaryl-1,3-benzodiazepines and

A compound of the formula ##STR1## wherein R.sup.1 is hydrogen, loweralkyl, phenyl, phenyl substituted by one or more loweralkyl, loweralkoxy, halogen, or trifluoromethyl groups, phenylloweralkyl or phenylloweralkyl in which the phenyl group is substituted by one or more loweralkyl, loweralkoxy, halogen, or trifluoromethyl groups; R.sup.2 is loweralkyl, furanylloweralkyl, thienylloweralkyl, pyrrolylloweralkyl, pyridinylloweralkyl, phenylloweralkyl, or phenylloweralkyl in which the phenyl group is substituted by one or more loweralkyl, loweralkoxy, halogen, or trifluoromethyl groups; X is hydrogen, loweralkyl, loweralkoxy, halogen, or trifluoromethyl; m is 0 or 1; n is 1 or 2; an optical isomer thereof or a salt thereof.

2-(4-piperidinyl)-1H-pyrido[4,3-b]-indol-1-ones and related compounds

2-(4-pyrrlidinyl)-1H-pyrido[4,3-b]indol-1-ones and related compounds

A process of synthesizing a compound of the formula 1: ##STR1## is disclosed, which comprises reacting a compound of the formula 2: ##STR2## with diphenylphosphine in the presence of an amine base and a nickel catalyst to produce a compound of formula 1.

Process of synthesizing binaphthyl derivatives

A compound of the formula ##STR1## wherein R.sup.1 is hydrogen, loweralkyl, phenyl, phenyl substituted by one or more loweralkyl, loweralkoxy, halogen, or trifluoromethyl groups, phenylloweralkyl or phenylloweralkyl in which the phenyl group is substituted by one or more loweralkyl, loweralkoxy, halogen, or trifluoromethyl groups; R.sup.2 is loweralkyl, furanylloweralkyl, thienylloweralkyl, pyrrolylloweralkyl, pyridinylloweralkyl, phenylloweralkyl, or phenylloweralkyl in which the phenyl group is substituted by one or more loweralkyl, loweralkoxy, halogen, or trifluoromethyl groups; X is hydrogen, loweralkyl, loweralkoxy, halogen, or trifluoromethyl; m is 0, 1 or 2; n is 1 or 2; an optical isomer thereof or a salt thereof.

2-(4-piperidinyl)-1H-pyrido[4,3-B]indol-1-ones and related compounds

Growing community of inventors

Somerset, NJ, United States of America

Joseph F Payack