The Schepens Eye Research Institute, Inc.

Massachusetts Eye and Ear Infirmary

The General Hospital Corporation

Banner Health

Joseph F Arboleda-Velasquez

Leo A Kim

Dean Eliott

Eric M Reiman

Patricia A D'Amore

Dhanesh Amarnani

Yakeel T Quiroz

Francisco Lopera

The invention provides ocular formulations and features a nano-emulsion composition, e.g., a nano-emulsion comprising a CBFβ-RUNX1 inhibitor. The composition comprises a particle with a length of less than 200 nanometers in at least one dimension.

Nano-emulsion of CBFβ-RUNX1 inhibitor for ocular drug deliver

Methods and compositions for preventing or treating cognitive decline associated with dementia and/or mild cognitive impairment and/or neurodegeneration using antibodies, peptides, fusion proteins, or genome editing systems that modulate HSPG/heparin binding affinities of ApoE.

Anti-ApoE antibodies and polynucleotides thereof

The present subject matter provides, inter alia, compositions, systems, kits, and methods for diagnosing and treating small vessel diseases (SVDs).

Blood biomarkers and diagnostic methods for small vessel diseases

The present subject matter provides compositions, formulations and methods for preventing or reducing proliferation or migration of retinal cells or epithelial to mesenchymal transition in ocular cells or cells from other tissues.

RUNX1 inhibition for treatment of proliferative vitreoretinopathy and conditions associated with epithelial to mesenchymal transition

The invention provides ocular formulations and features a nano-emulsion composition, e.g., a nano-emulsion comprising a CBF&#x3b2;-RUNX1 inhibitor. The composition comprises a particle with a length of less than 200 nanometers in at least one dimension.

Nano-emulsion of CBF&#xdf;-RUNX1 inhibitor for ocular drug delivery

The present subject matter provides, inter alia compositions, formulations, and methods for inhibiting, treating, and preventing small vessel diseases.

NOTCH3 agonist compositions and methods for treating small vessel diseases

The present subject matter provides compositions, formulations, and methods for inhibiting, treating, or preventing aberrant angiogenesis in a subject.

Growing community of inventors

Newton, MA, United States of America

Joseph F Arboleda-Velasquez