US Government as Represented by the Secretary of the Army

Interx Research Corporation

Joseph Epstein

Nicholas S Bodor

George T Davis

John A Parsons

Constance W Gould

Harry O Michel

John J Norman

Theodore Mill

Frank Block

Leon J Schiff

Joseph H Fleisher

Robert E Plapinger

John J Callahan

Lewis M Berkowitz

Robert M Heggie

Bernard J Jandorf

A method of simulating a positive response by volatile organophosphorus ers to an ionization detector system which comprises forwarding to the ionization detector system a gaseous stream comprising water vapor and a di(lower alkyl) sulfoxide or a cyclic sulfoxide represented by the formula I: ##STR1## wherein R is hydrogen or a lower alkyl group, in an amount sufficient to elicit a positive response by the ionization detector system.

Use of sulfoxides for testing ionization detector system

The compounds of S-(2-dialkylaminoalkyl) alkyl phosphonothioic acids and hod of preparing said compounds possessing anticholinesterase activity comprising an aqueous solution which comprises dialkylaminoalkyl chloride salts which are converted to their corresponding dialkylmonoalkyl ammonium ions and alkylphosphonothioic acids forming a reaction mixture. The latter mixture is placed on a cation exchange resin with subsequent addition of water as an eluting agent giving rise to fractions containing the desired compounds.

Process for making compounds possessing anticholinesterase activity

Novel pyridiniumaldoximes having micellar characteristics are useful in the deactivation of organophosphates. Fast and effective detoxification of areas and equipment contaminated with organophosphate pesticides and insecticides results from use of the reagents.

Novel pyridiniumaldoximes having micellar characteristics

A method for oxidatively degrading organophosphorous esters to phosphoric id, carbon dioxide and water through the use of a source of free hydroxy radicals, saturation of the resulting solution with oxygen and subsequent irradiation with UV radiation between 220 and 280 nm.

Method of oxidative degradation of phosphorous esters

A method of preparing anticholinesterase organophosphoro and organophosph-fluoridates, e.g., GB in situ by mixing a phosphorous ester in an aprotic solvent with a solution of tetraethylammonium in the same solvent.

Process for preparing organophosphorus and organophosphono fluorines

A method comprising an unknown solution adding an organophosphorus thio a salt solution for sufficient time to form compounds having anticholinesterase activity in the reaction solution, contacting the reaction solution with a cholinesterase supported on a suitable substrate, adding indoxyl acetate and observing a non-color or blue color change in the substrate; the absence of color indicates the formation of compounds with anticholinesterase activity and the blue color of the substrate indicating that there was no formation of compounds with anticholinesterase activity.

Detection and estimation of microquantities of alkylating agents

A method of challenging an agent alarm for the detection of V and G agents hrough the use of a simulant compound which has no significant toxicity and which will test the three principal components of the alarm, namely the conversion filler, heating element, and the detection cell. The stimulant compound has the general formula ##STR1## wherein R' is a lower alkyl group selected to produce a readily displaced alkylmercapto moiety when reacted with the AgNO.sub.3 and KF of the conversion filter and R is a longer chain alkyl selected to give a volatility similar to that of less volatile G agents.

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Baltimore, MD, United States of America

Joseph Epstein