University of Rochester

Colorado State University Research Foundation

Joseph E Wedekind

Brian R McNaughton

Harold C Smith

Ivan A Belashov

David W Crawford

Benjamin L Miller

Charles A Thornton

Peter C Gareiss

Krzysztof Sobczak

Ryan Patrick Bennett

Simple &#x3b2;-hairpin peptides in linear and cyclic form that specifically bind to HIV-1 Trans-Activation Response element (HIV-1 TAR), as well as compositions and use thereof are described.

Anti-HIV peptides

The present invention relates to homo- and hetero-dimer compounds formed by a disulfide, sulfinyl thio, or olefin bond between two monomers. A method of making a homo- or hetero-dimer compound is also disclosed. The present invention also relates to monomer compounds capable of forming homo- or hetero-dimer compounds, as well as oligomers formed via linkage of one or more dimers. Also disclosed are methods of inhibiting the activity of target RNA molecules, particularly those having a secondary structure that include a stem or stem-loop formation. Dimer compounds capable of inhibiting the activity of an HIV-I RNA frameshifting stem-loop and a (CUG)n expanded repeat stem-loop are disclosed, as are methods of treating diseases associated with these target RNA molecules. The dimer compounds can also be used for selectively detecting presence of the target RNA molecule in a sample.

Nucleic acid binding compounds and methods of use

Disclosed are methods and compositions related to the structure and function of APOBEC3G.

Methods and compositions related to the structure and function of APOBEC3G

This invention relates to cytidine deaminase inhibitors (Cytidine deaminase inhibitors) of cytidine deaminases and uses thereof.

Content dependent inhibitors of cytidine deaminases and uses thereof

Growing community of inventors

Rochester, NY, United States of America

Joseph E Wedekind