Nitromed, Inc.

Natureworks LLC

Nicox S.a.

Nagoya University

Roquette Freres

Hitachi Zosen Corporation

Tohoku Electric Power Company, Inc.

Furanix Technologies B.v.

Boston Brands, Inc.

Joseph David Schroeder

David S Garvey

Xinqin Fang

Stewart K Richardson

L Gordon Letts

Subhash P Khanapure

Cheri A Stevenson

Richard A Earl

Ramani R Ranatunge

Maiko Ezawa

Shiow-Jyi Wey

Inigo Saenz De Tejada

Ricky D Gaston

Upul Keerthi Bandarage

Chia-En Lin

Tiansheng Wang

Sang William Tam

Aman Kulshrestha

Richard Douglas Benson

Ramani R Bandarage

Gregory J Mercer

Qing Dong

Takashi Hasegawa

Gerardus Johannes Maria Gruter

Jeffrey John Kolstad

Matheus Adrianus Dam

Nicolas Jacquel

René Saint-Loup

Laszlo Sipos

Hisanori Kishida

Manuel A W Natal

Eric Stanley Sumner

Ramani R Ranatunga

Nobuyoshi Nomura

Makoto Takahashi

Laura Mae Babcock

Tatiana E Shelekhin

Inigo Saenez De Tejada

Krag Ellis Anderson

Oliver J Palardy

James Russell Valentine

Manuel Aw Natal

Gabriel Degand

Steven Scott Bray

J Chad Scales

Manuel AW Natal

Manuel Natal

Laura M Babcock

Polylactide resin compositions that exhibit rapid hydrolysis rates and leave small amounts of residuals include a poly(meso-lactide) and a second polylactide. The polylactide resin compositions are useful in applications in which rapid hydrolysis is wanted under mildly to moderately elevated temperatures, such as in certain oil & gas well treatment applications.

Fast-hydrolyzing polylactide resin compositions

2-Acetoxyalkanoic acid esters are made in a reaction of a 3,6-dialkyl-1,4-dioxane-2,5-dione or a poly(&#x3b1;-hydroxyalkanoic acid), an acetate ester and an alcohol or phenol in the presence of a transesterification catalyst. Unlike previous methods for making 2-acetoxyalkanoic acid esters, this process proceeds in high yield and high selectivity to the desired product.

Process for making esters of 2-acetoxyalkanoic acids using a 3,6-dialkyl-1,4-dioxane-2,5-dione or poly-(alpha-hydroxyalkanoic acid) as a starting material

A polyester including at least one furandicarboxylate unit, at least one saturated, linear or branched, diol unit including from 2 to 10 carbon atoms, and at least one bicyclic diol unit, the said bicyclic diol being chosen from: isosorbide, isoidide, isomannide, 2,3:4,5-di-O-methylene-galactitol, and 2,4:3,5-di-O-methylene-D-mannitol. The glass transition temperature of the polyester is greater than or equal to 90&#xb0; C. Processes for preparing this polyester are also described.

Polyesters comprising 2,5-furandicarboxylate and saturated diol units having a high glass transition temperature

2-Acetoxyalkanoic acid esters are made in a reaction of an &#x3b1;-hydroxyalkanoic acid ester and an acetate ester in the presence of a transesterification catalyst. Unlike previous methods for making 2-acetoxyalkanoic acid esters, this process proceeds in high yield and high selectivity to the desired product.

Process for making esters of 2-acetoxyalkanoic acids using an &#x3b1;-hydroxyalkanoic acid ester and an acetate ester as starting materials

This invention provides a method for synthesizing semi-crystalline polylactides (PLA) even from a lactide mixture including meso-LA and rac-LA. According to the invention, when a mixture of racemic lactide and meso-lactide ispolymerized using a catalyst capable of iso-selectively polymerizing L-lactide and D-lactide, an amorphous poly (meso-lactide) block is formed from meso-lactide and a semi-crystalline poly (racemic lactide) block is formed from racemic lactide by separately polymerizing racemic lactide and meso-lactide by taking advantage of a difference in physicochemical properties between racemic lactide and meso-lactide, whereby polylactide which is semi-crystalline as a whole is produced.

Method to produce semi-crystalline polylactides

Lactic acid equivalents are recovered from a starting lactide stream by catalytically racemizing a portion of the lactide in the stream at a temperature of 180&#xb0; C. or below. This increases the proportion of two species of lactide (i.e., at least two of S,S-, R,R- or meso-lactide) at the expense of the third species. The racemized mixture so obtained can be separated to recover some or all of one or more of the lactide species from the remaining lactide species, by a process such as melt crystallization or distillation. Impurities in the starting lactide stream usually are retained mostly in the remaining meso-lactide, so a highly purified S,S- and/or R,R-lactide stream can be produced in this manner. Such a purified S,S- and R,R-lactide stream is suitable for polymerization to form a polylactide.

Recovery of lactic acid values from a meso-lactide stream

The invention describes novel nitrosated nonsteroidal antiinflammatory drugs (NSAIDs) and pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated NSAID, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or at least one therapeutic agent. The invention also provides novel compositions comprising at least one nitrosated NSAID, and at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one therapeutic agent. The invention also provides novel kits comprising at least one nitrosated NSAID, and, optionally, at least one nitric oxide donor and/or at least one therapeutic agent. The invention also provides methods for treating inflammation, pain and fever; for treating gastrointestinal disorders; for facilitating wound healing; for treating and/or preventing gastrointestinal, renal and/or respiratory toxicities resulting from the use of nonsteroidal antiinflammatory compounds; for treating inflammatory disease states and/or disorders; and for treating and/or preventing ophthalmic diseases and/or disorders.

Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use

Polyester-carbonate copolymers are prepared by copolymerizing lactide with a 1:4-3:6 dianhydrohexitol in the presence of a carbonate precursor and a polymerization catalyst. The copolymers have an elevated glass transition temperature, relative to polylactide resins.

Method for making copolymers of lactide and a 1:4-3:6 dianhydrohexitol

The invention also provides methods for treating inflammation, pain and fever; for treating gastrointestinal disorders; for facilitating wound healing; for treating and/or preventing gastrointestinal, renal and/or respiratory toxicities resulting from the use of nonsteroidal antiinflammatory compounds; for treating inflammatory disease states and/or disorders; and for treating and/or preventing ophthalmic diseases and/or disorders comprising administration of novel compositions comprising at least one nitrosated NSAID, and, optionally, at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one therapeutic agent.

Metal catalyst residues in resins containing polymerized lactic acid units, such as polylactides, are deactivated by treatment with a polymer or copolymer that contain pendant acid groups and pendant ester groups, with an acid-containing PLA resin, or with a polymer or copolymer having at least one acid groups per 250 atomic mass units and which has pendant lactic acid or poly(lactic acid) groups. The deactivating agent is effective at deactivating the catalyst, and has little effect on the optical clarity of the resin.

Method for stabilizing polymers containing repeating lactic acid units, and stabilized polymers so made

The invention describes novel nitrosated nonsteroidal anti-inflammatory drugs (NSAIDs) and pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated NSAID, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or at least one therapeutic agent. The invention also provides novel compositions comprising at least one nitrosated NSAID, and at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one therapeutic agent. The invention also provides novel kits comprising at least one nitrosated NSAID, and, optionally, at least one nitric oxide donor and/or at least one therapeutic agent. The invention also provides methods for treating inflammation, pain and fever; for treating gastrointestinal disorders; for facilitating wound healing; for treating and/or preventing gastrointestinal, renal and/or respiratory toxicities resulting from the use of nonsteroidal antiinflammatory compounds; for treating inflammatory disease states and/or disorders; and for treating and/or preventing ophthalmic diseases and/or disorders.

The present invention relates to an anti-microbial packaging polymer and its method of use, and more particularly to a contact anti-microbial such as quaternary ammonium and phosphonium salts covalently bound to a polymeric material that may be suitable in a variety of applications such as film and container packaging of foodstuffs, cosmetics, medical equipment and devices, environmental, hygienic and sanitary applications, as well as other consumer and commercial use. This anti-microbial polymer has the benefit of being bactericidal, fungicidal, and/or viricidal. For example, this anti-microbial feature may result in additional shelf life of the foodstuff contained in the anti-microbial packaging polymer of the present invention.

Method of preserving food using antimicrobial packaging

Growing community of inventors

Minneapolis, MN, United States of America

Joseph David Schroeder