Enanta Pharmaceuticals, Inc.

Joseph D Panarese

Yat Sun Or

Jianming Yu

In Jong Kim

Brian Christopher Shook

Thomas P Blaisdell

Samuel Bartlett

Dexter Davis

Nathaniel Thomas Kenton

Guoqiang Wang

Katherine Chong

Hui Cao

Xiaowen Peng

Xuechao Xing

Ruichao Shen

Xuri Gao

Yong He

Jiajun Zhang

Jun Ma

Wei Li

Kevin McGrath

Solymar Negretti-Emmanuelli

Sean M Rafferty

Kai Lin

Michael H J Rhodin

Nicole V McAllister

Jorden Kass

Byung-Chul Suh

Sean Rafferty

Matthew C Rhodes

Jonathan Thielman

Michael HJ Rhodin

The present invention discloses compounds of Formula (I), and pharmaceutically acceptable salts, thereof: which inhibit coronavirus replication activity. The invention further relates to pharmaceutical compositions comprising a compound of Formula (I) or a pharmaceutically acceptable salt thereof, and methods of treating or preventing a coronavirus infection in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of Formula (I) or a pharmaceutically acceptable salt thereof.

Spiropyrrolidine derived antiviral agents

Macrocyclic spiropyrrolidine derived antiviral agents

The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit Respiratory Syncytial Virus (RSV). The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from RSV infection. The invention also relates to methods of treating an RSV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

Benzodiazepine derivatives as RSV inhibitors

The present invention relates to a pharmaceutical composition useful for treating a Respiratory Syncytial Virus (RSV) infection, comprising a compound which is or a pharmaceutically acceptable salt thereof, and a second anti-respiratory syncytial virus agent.

Combination pharmaceutical agents as RSV inhibitors

The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, thereof: which inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV life cycle of the hepatitis B virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HBV infection. The invention also relates to methods of treating an HBV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

Functionalized heterocycles as antiviral agents

Heterocyclic antiviral agents

Saturated spirocyclics as antiviral agents

Alkyne-containing antiviral agents

Functionalized heterocyclic compounds as antiviral agents

The present invention discloses compounds of Formula (I), and pharmaceutically acceptable salts thereof: which inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV life cycle of the hepatitis B virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HBV infection. The invention also relates to methods of treating an HBV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

Substituted heterocycles as antiviral agents

The present invention discloses compounds of Formula (Ia), and pharmaceutically acceptable salts, thereof: which inhibit coronavirus replication activity. The invention further relates to pharmaceutical compositions comprising a compound of Formula (Ia) or a pharmaceutically acceptable salt thereof, and methods of treating or preventing a coronavirus infection in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of Formula (Ia) or a pharmaceutically acceptable salt thereof.

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Malden, MA, United States of America

Joseph D Panarese