Diagnostic Hybrids, Inc.

Ohio University

Health Research, Inc.

Diagnostic Research Limited Partnership

Joseph D Jollick

David R Scholl

Jill Taylor

Laura Gillim-Ross

David E Wentworth

The invention provides compositions and methods for detecting the presence of SARS-coronavirus, for screening anti-SARS coronavirus agents and vaccines, and for reducing infection with plus-strand RNA viruses such as SARS-coronavirus.

Compositions and methods for detecting a non plus-stranded RNA virus

Compositions and methods for detecting severe acute respiratory syndrome coronavirus

The present invention generally relates to the field of diagnostic virology. More particularly, the present invention is directed to methods and compositions useful for the detection and differentiation of viral particles and/or virions in specimens. The present invention also provides methods and compositions useful for evaluating the susceptibility of infectious viruses to antiviral agents.

Compositions and methods for detecting viral infection

Methods for the detection and identification of unknown pathogens or genetic entities from samples suspected of containing the same involve the use of novel wicking techniques whereby sample DNA/RNA becomes readily available on a porous, inert, positively charged support in single stranded form for hybridization with a hybridization probe having a nucleotide sequence substantially complementary to a nucleotide sequence of the sample DNA/RNA. Such methods permit the detection and identification of unknown pathogens and genetic entities in a shorter period of time than that required by conventional methods. Lysis solutions for rapidly lysing bacterial cells without the aid of enzymes are also disclosed.

Methods for the in vitro detection and identification of unknown

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Athens, OH, United States of America

Joseph D Jollick