Alza Corporation

Corium International, Inc.

Bluegrass Vascular Technologies, Inc.

Other

Merit Medical Systems, Inc.

Shifamed Holdings, LLC

Benvenue Medical, Inc.

Intarcia Therapeutics, Inc.

Corium Corporation

Kalila Medical, Inc.

Corium Pharma Solutions, Inc.

Joseph Creagan Trautman

Parminder Singh

Robert Wade Worsham

Richard L Keenan

Steven Richard Klemm

Danny Lee Bowers

Guohua Chen

Michel J N Cormier

Danir F Bayramov

John Gurley

Brice Arnault De La Menardiere

Clayton Baldwin

Laurent B Schaller

Peter E Daddona

Hyunok Lynn Kim

Amr Salahieh

Tom Saul

Anthony Le

Colin Mixter

Douglas Joseph Scott Bourne

James Matriano

Marc Bitoun

WeiQi Lin

Andy Klemm

Ahmad P Samiee

Jean-Pierre Dueri

Richard Joseph Renati

Lorin Philip Olson

Jonah Lepak

Christopher T Cheng

Emma Lepak

Michael T Cao

Esi Ghartey-Tagoe

Janet Wendorf

Andrew Richard Klemm

Steve Williams

J Richard Gyory

Alan K Schaer

Armand P Neukermans

Michel J Cormier

Patrick S-l Wong

Emma Leung

Michael G Zuck

Cedric T Wright

Todor Jeliaskov

Wai-Loong Lim

Wei-Qi Lin

Andrew I Poutiatine

Appala Sagi

Michel Jn Cormier

Kellee Eng

Sara L Sendelbeck

Bruce P Edwards

Danir Bayamov

Steven Richard Kelmm

Andy Kelmm

A catheter system for accessing the central venous system through an occlusion in the neck region.

Occlusion access systems

Occlusion access method

An applicator for a microprojection array is described. In one embodiment, the applicator comprises an energy-storing element. Application of force causes the compressed energy-storing element to extend or transition from first and second configurations, releasing stored energy to deploy a holding member in the application which is configured to hold an array of microprojections. In another embodiment, the applicator comprises an energy storing element with two stable configurations, a first stable configuration and second stable configuration. Application of force causes the energy-storing element to transition from the higher energy first stable configuration to the lower energy second stable configuration, releasing the difference in energies of the two states to deploy a holding member in the application which is configured to hold an array of microprojections.

Applicators for microneedles

Steerable medical devices and methods of use. In some embodiments, the steerable medical devices can be steered bi-directionally. In some embodiments the steerable medical devices include a first flexible tubular member and a second flexible tubular member secured together at a location distal to a steerable portion of the steerable medical device.

Steerable medical devices, systems, and methods of use

Methods and systems for closing an opening or defect in tissue, closing a lumen or tubular structure, cinching or remodeling a cavity or repairing a valve preferably utilizing a purse string or elastic device. The preferred devices and methods are directed toward catheter-based percutaneous, transvascular techniques used to facilitate placement of the devices within lumens, such as blood vessels, or on or within the heart to perform structural defect repair, such as valvular or ventricular remodeling. In some methods, the catheter is positioned within the right ventricle, wherein the myocardial wall or left ventricle may be accessed through the septal wall to position a device configured to permit reshaping of the ventricle. The device may include a line or a plurality of anchors interconnected by a line. In one arrangement, the line is a coiled member.

Catheter-based tissue remodeling devices and methods

Medical tool positioning and control devices, systems, and methods. Handle assemblies that allow a steerable shaft to be steered, while allowing the separate movement of a medical tool. The handle assemblies can allow for rotation and axial movement of the medical tool, and optionally with an actuator disposed distal to a second actuator that controls steering of the steerable shaft.

Medical tool positioning devices, systems, and methods of use and manufacture

Steerable medical devices and methods of use. In some embodiments, the steerable medical devices include a steerable portion with a stiffness that varies along the length of the steerable portion.

An applicator device () is provided for applying a patch () having an array of microprotrusions () to the stratum corneum. The applicator device () includes a device body () and a piston moveable within the device body (). A cap () is provided on the device body () for activating the device () to impact the stratum corneum with a microprotrusion array (). The device () is capable of being cocked by one handed operation of the user which allows the device () to be used by patients having neither the strength nor the manual dexterity to cock other types of applicator devices.

Microblade array impact applicator

In an aspect of the invention, an array of microprotrusions is formed by providing a mold with cavities corresponding to the negative of the microprotrusions, casting atop the mold a first solution comprising a biocompatible material and a solvent, removing the solvent, casting a second solution atop the first cast solution, removing the solvent from the second solution, and demolding the resulting array from the mold. The first solution preferably contains an active ingredient.

Solvent-cast microprotrusion arrays containing active ingredient

Occlusion access system

A microprojection array is provided, comprising an approximately planar base and a plurality of microprojections, wherein the array comprises a vaccine and a polymeric material. The array may have multiple layers. The vaccine may be placed in only one layer. In another embodiment of the invention, a method of preventing a disease is provided, comprising insertion into the skin of a patient an array of microprojections comprising a layer which comprises a vaccine for that disease and a polymer.

Method of vaccine delivery via microneedle arrays

Growing community of inventors

Sunnyvale, CA, United States of America

Joseph Creagan Trautman