Nellcor Puritan Bennett Incorporated

Zeltiq Aesthetics, Inc.

Covidien LP

Joseph Coakley

George L Matlock

Darius D Eghbal

William Raridan

Don Hannula

Paul David Mannheimer

William Patrick Pennybacker

Adnan I Merchant

John W Allison

Michael Patrick O'Neil

Bryan Jon Weber

Rodney P Chin

Mark William Baker

Peter Yee

Jesse Nicasio Rosen

Paul William Martens

Albert L Ollerdessen

Mitchell Elliott Levinson

George Frangineas, Jr

Robert W Flagler

Thomas Burnell Reeve, Iii

Donald Scott Nelson

Michael H Vardanega

John C Potosky

Robert Jochim

Tamara Hilton

Tamara Lynn Hilton

Devices, systems and methods for removing heat from subcutaneously disposed lipid-rich cells are disclosed. In selected embodiments, suction and/or heat removal sources are coupled to an applicator. The applicator includes a flexible portion and a rigid portion. The rigid portion includes a thermally conductive plate and a frame coupling the thermally conductive plate and the flexible portion. An interior cavity of the applicator is in fluid communication with the suction source, and the frame maintains contiguous engagement between the heat removal source and the thermally conductive plate.

Device, system and method of removing heat from subcutaneous lipid-rich cells

Application systems, disposable interface assemblies and methods for cooling subcutaneous lipid-rich tissue. One embodiment of an application system includes a cooling unit, a cryoprotectant vessel, a contact member and an array of selectively addressable heating elements. The cryoprotectant vessel is configured to contain a fluidic cryoprotectant such that at least a portion of the cryoprotectant is cooled by the cooling unit to a desired base temperature. The contact member is attached to the cryoprotectant vessel and includes a backside in contact with the cryoprotectant and a front side opposite the backside. The contact member is configured to allow the cryoprotectant to flow from the backside to the front side. The array of selectively addressable heating elements is carried by the contact member.

Devices, application systems and methods with localized heat flux zones for removing heat from subcutaneous lipid-rich cells

Treatment systems include conformable applicators for performing cryotherapy are described. Aspects of the technology are further directed to methods and conformable applicators capable of affecting target regions. The conformable applicators can be applied a wide range of treatment sites. A strap assembly can hold applicator against the treatment site, and a holder assembly can be adhered to the subject's skin to inhibit, limit, or substantially prevent movement of the applicator along the subject's skin.

Treatment systems, devices, and methods for cooling targeted tissue

Systems for treating a subject's tissue can include a thermally conductive cup, a tissue-receiving cavity, and a vacuum port. The vacuum port is in fluid communication with the tissue-receiving cavity to provide a vacuum for drawing the submental tissue, or other targeted tissue, into the tissue-receiving cavity. A thermal device can cool and/or heat the conductive cup such that the conductive cup non-invasively controls the temperature of subcutaneous lipid-rich cells in the tissue. A restraint apparatus can hold a the conductive cup in thermal contact with the target region.

Treatment systems, small volume applicators, and methods for treating submental tissue

Home-use applicators for non-invasively removing heat from subcutaneous, lipid-rich cells via phase change coolants, and associated devices, systems and methods. A device in accordance with a particular embodiment includes an applicator releasably positionable in thermal communication with human skin, and a coolant vessel having a coolant. The device further includes a heat transfer conduit operatively coupled to the applicator and housing a heat transfer fluid that is isolated from fluid contact with the coolant. A heat exchanger is operatively coupled between the coolant vessel and the heat transfer conduit to transfer heat between the heat transfer fluid and the coolant, and a fluid driver is operatively coupled to the heat transfer conduit to direct the heat transfer fluid between the applicator and the heat exchanger.

Home-use applicators for non-invasively removing heat from subcutaneous lipid-rich cells via phase change coolants

A treatment system for cooling subcutaneous lipid-rich cells in a human subject includes an applicator and a control unit. The treatment system has a cooling mode for cooling tissue and a heating mode for warming tissue. The control unit includes a circulation circuit in fluid communication with the applicator, a chiller apparatus configured to chill fluid from the applicator circulation circuit, and a heater apparatus to warmed fluid from the applicator circulation circuit. The control unit mixes the chilled fluid and/or the warmed with fluid in the applicator circulation circuit control the temperature of the fluid circulated in the applicator.

Treatment systems with fluid mixing systems and fluid-cooled applicators and methods of using the same

Cryotherapy applicator for cooling tissue

An optical sensor, having a cover layer, an emitter disposed on a first side of the cover, a detector disposed on the first side of said cover, and a plurality of stacked independent adhesive layers disposed on the same first side of the cover, wherein the top most exposed adhesive layer is attached to a patient's skin. Thus, when the sensor is removed to perform a site check of the tissue location, one of the adhesive layers may also be removed and discarded, exposing a fresh adhesive surface below for re-attachment to a patient's skin. The independent pieces of the adhesive layers can he serially used to extend the useful life of the product.

Stacked adhesive optical sensor

An optical sensor having a cover layer, an emitter disposed on a first side of the cover, a detector disposed on the first side of said cover, and a plurality of stacked independent adhesive layers disposed on the same first side of the cover, wherein the top most exposed adhesive layer is attached to a patient's skin. Thus, when the sensor is removed to perform a site check of the tissue location, one of the adhesive layers may also be removed and discarded, exposing a fresh adhesive surface below for re-attachment to a patient's skin. The independent pieces of the adhesive layers can be serially used to extend the useful life of the product.

A bi-stable sensor is provided that includes a frame upon which electrical and optical components may be disposed and a coating, such as an overmold coating, provided about the frame. A resistance-providing component is provided integral with or external to the coated bi-stable sensor such that the bi-stable sensor has two mechanically stable configurations that may be transitioned between by overcoming the resistance provided by the resistance-providing component and/or the by the coating. In one embodiment, the resistance-providing component comprises an elastic band provided about a hinge of the frame, either within or external to the coating. In one embodiment, the sensor may be placed on a patient's finger, toe, ear, and so forth to obtain pulse oximetry or other physiological measurements.

Bi-stable medical sensor and technique for using the same

A method for manufacturing a sensor is provided. The method includes providing a frame having a loop structure, and covering the frame with a coating material to provide a sensor body having at least one diaphragm structure. The one or more diaphragm structures of the sensor body bias an emitter housing and a detector housing of the frame toward one another. The sensor may be placed on a patient's finger, toe, and so forth, to obtain pulse oximetry or other physiological measurements.

Methods of manufacturing a compliant diaphragm medical sensor

Embodiments of the present disclosure relate generally to a sensor assembly. In various embodiments the sensor assembly includes a body having a first segment, a second segment, and a living hinge. The living hinge has a pivot axis and mechanically couples the first segment and the second segment. Further, the living hinge facilitates the first segment and the second segment to pivoting relative to one another about the pivot axis. Embodiments may also relate to a method of manufacturing a sensor frame. The method may include forming an integral sensor body having a first frame segment, a second frame segment, and a living hinge. The first frame segment and the second frame segment are configured to pivot relative to one another about a pivot axis of the living hinge. The method may also include coupling one or more biasing mechanisms to the first frame segment and the second frame segment. The biasing mechanism is configured to generate a moment about the pivot axis of the living hinge. The moment biases the first segment and second segment into a closed position.

Growing community of inventors

Dublin, CA, United States of America

Joseph Coakley