Eli Lilly and Company

Joseph Chiou-Chung Tang

Joseph Matthew Colacino

John E Munroe

William Joseph Hornback

Louis Nickolaus Jungheim

Wayne A Spitzer

Patti J Treadway

Frantz Victor

Shawn Christopher Miller

Mark Joseph Tebbe

Beverly Ann Heinz

Jo Ann Hoskins

Scott C Mauldin

Genshi Zhao

Kirk Alan Staschke

Mark Ayer Muesing

Steven Duane Hatch

The invention provides isolated nucleic acid compounds encoding gcp of,. Also provided are vectors and transformed host cells for expressing the encoded protein, and a method for identifying compounds that bind and/or inhibit said protein.

Streptococcus pneumoniae gene sequence GCP

Anti-viral method

The invention provides isolated nucleic acid compounds encoding dpj of Streptococcus pneumoniae. Also provided are vectors and transformed host cells for expressing the encoded protein, and a method for identifying compounds that bind and/or inhibit said protein.

Streptococcus pneumoniae gene sequence Dpj

The present invention provides a method of inhibiting influenza and flaviviral replication based on a mechanism of action in which HA-mediated fusion or E protein mediated fusion is inhibited by a fusion inhibiting agent which binds, complexes or otherwise becomes associated with HA or E protein during the translation of the target protein and/or its vesicular transport.

Inhibition of viral replication

A series of benzimidazole compounds having the following general structure are provided which inhibit the growth of picornaviruses (e.g., rhinoviruses, enteroviruses, polioviruses, coxsackieviruses of the A and B groups, echo virus and Mengo virus) and flaviviruses (e.g., hepatitis C and bovine diarrheal virus). ##STR1## A method for inhibiting picornaviruses and flaviviruses is also provided which includes administering to a host an effective amount of the inventive benzimidazole compounds.

Anti-viral compound

The present application provides a series of benzimidazole compounds which inhibit the growth of picornaviruses, such as rhinoviruses, enteroviruses, polioviruses, coxsackieviruses of the A and B groups, echo virus and Mengo virus and flaviviruses such as hepatitis C and bovine diarrheal virus.

Anti-viral compounds

Growing community of inventors

Carmel, IN, United States of America

Joseph Chiou-Chung Tang