Bayer Corporation

Siemens Healthcare Diagnostics Gmbh

Joseph Carlucci

Bruce E Behringer

James A Mawhirt

Gregory A Farrell

Nicolae Dumitrescu

John F Cremins

Loretta Catania

The valve sealing system for a reagent package includes an annular cylindrical gasket seated in a channel formed in the package. A rocker valve on the package pivots relative to the annular cylindrical gasket which surrounds an opening to the chamber of the reagent package. The annular channel includes a radially inner peripheral channel sidewall, a radially outer peripheral channel sidewall, and a bottom portion. An inclined peripheral wall portion of the channel intersects one of the channel sidewalls at an obtuse angle and the bottom portion of the channel. When the rocker valve is in a valve closed position it engages the annular cylindrical gasket to provide a substantially leak-tight seal.

Valve sealing system for a reagent package

An integral heated reaction chamber for use in a unified fluid circuit having an acrylic body. The acrylic body is preferably formed of first and second acrylic layers bonded or fused together. A chamber half is formed in each of the acrylic layers and the layers are bonded together in opposition. A thinning notch is provided in one of the acrylic layers to form a thin wall of the chamber, and a heater element is secured adjacent the thin wall to heat the contents of the chamber. A temperature sensor is provided to monitor the temperature of the chamber contents. The sensed temperature may be used to control the heating element and the heating time according to a predetermined reaction protocol.

Heated reaction chamber in a unified fluid circuit of a hematology

A unified fluid cell circuit assembly for an analytical instrument, such as a clinical hematology, immunoassy or chemistry or a flow cytometry instrument. The assembly includes a unified fluid circuit, a shear valve, a fluid pump assembly, and a plurality of solenoid valves. The unified fluid circuit is made of a plurality of acrylic plates which have formed in the various plate surfaces chamber cavities, pneumatic, hydraulic and vent line, and valve cavities. The plates, when secured together, form a plurality of reaction chambers, a plurality of control valves and various lines as a network for controlling the flow and mixing of aliquots of a sample and fluids (rinse, reagents, etc.) to perform the reactions for analyzing the sample. The fluid pump assembly is connected to the unified flow circuit and has a plurality of diaphragm pumps which pump precise volumes of fluids. The solenoid valves provide the pressure and vacuum to operate the pumps and to provide a sample into the shear valve to form sample aliquots, and to mix the various aliquots with the reagents and diluents to form the reaction mixtures.

Unified fluid circuit assembly for a clinical hematology instrument

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Harrison, NY, United States of America

Joseph Carlucci