Alza Corporation

Joseph C Deters

Felix T Theeuwes

James B Eckenhoff

Patrick S Wong

Brian L Barclay

David R Swanson

Atul D Ayer

Richard Lewis Cortese

Anthony L Kuczynski

George V Guittard

Terry L Burkoth

Stephen C DeRosa

Kevin J Mullins

A dispenser is disclosed for delivering a beneficial agent in a hydrophilic carrier formulation to an animal in a rate-controlled manner. The dispenser comprises (1) a semipermeable housing defining an internal space, (2) at least one composition comprising a beneficial agent and a pharmaceutically acceptable hydrophilic carrier in the space, (3) an expandable hydrophilic driving member in the space, (4) a density member in the space, and (5) one exit passageway or a multiplicity of exit passageways in the housing for delivering the beneficial agent from the dispenser, the diameter of each exit passageway being of a size to maximize release of the beneficial agent by osmotic pumping and to minimize release of the beneficial agent by diffusion or erosion to substantially avoid mechanical agitation-dependent release of the beneficial agent.

Controlled release dispenser comprising beneficial agent

A dosage form is disclosed comprising a member selected from the group consisting of nicardipine and its pharmaceutically acceptable salts for administering to a patient in need of cardio-vascular therapy.

Nicardipine therapy

A dispenser is disclosed for delivering a beneficial ionophore to an animal. The dispenser comprises (1) a semipermeable housing defining an internal space, (2) at least one composition comprising an ionophore and a pharmaceutically acceptable carrier in the space, (3) an expandable hydrophilic composition in the space, (4) a dense member in the space, and (5) at least one exit passageway in the housing for delivering the ionophore from the dispenser.

Dispenser comprising ionophore

A dosage form is disclosed comprising a member selected from the group consisting of nicardipine and its pharmaceutically acceptable salts for administering to a patient in need of cardiovascular therapy.

Dosage form for administering calcium antagonist nicardipine

A device is disclosed comprising a wall that surrounds a compartment. The compartment comprises a beneficial agent composition and a push composition. A passageway in the wall connects the compartment with the exterior of the device for delivering the beneficial agent at a rate governed, in combination, by the wall, the beneficial agent composition and the push composition through the passageway of the device over time.

Controlled-release system with constant pushing source

An osmotic dosage system is disclosed for delivering the therapeutically beneficial drug doxazosin to an environment of use over time.

Dosage form for dispensing drug for human therapy

A dispenser is disclosed for delivering a beneficial agent to an environment of use. The dispenser comprises a semipermeable wall surrounding a compartment containing a heat responsive composition, and an expandable composition. A passageway in the wall connects the compartment with the exterior of the dispenser.

Agent dispenser comprising a semipermeable wall surrounding single-piece

A method of forming a dispenser for delivering a beneficial agent to a biological environment. A beneficial agent and an expandable composition are placed in a capsule made of fluid dissolvable material. The capsule is closed and surrounded by a semipermeable wall which is permeable to fluid but not to the beneficial agent. Then a passageway is drilled in the capsule between the exterior and the interior which contains the beneficial agent.

Process for making dispenser with cooperating elements

An osmotic system is disclosed comprising a wall comprising in at least a part of a semipermeable material that surrounds a compartment. The compartment contains an osmotic composition comprising a beneficial drug selected from the group consisting of nifedipine, prazosin and doxazosin, and a second and different osmotic composition. A passageway in the wall connects the first composition with the exterior of the system.

Osmotic device for administering certain drugs

Drug dispenser comprising a multiplicity of members acting together for

A dispenser is disclosed for delivering a beneficial agent to an environment of use. The dispenser comprises a semipermeble wall surrounding a compartment containing a heat responsive composition, and an expandable composition. A passageway in the wall connects the compartment with the exterior of the dispenser.

Dispenser comprising inner positioned soft or hard capsule

Dispenser comprising capsule with volume displacing member

An osmotic device is disclosed for delivering a beneficial agent. The device comprises a wall surrounding a compartment containing drug, a passageway in the wall connecting the exterior of the device with the compartment, and drug in the wall. The device delivers the drug from the compartment and the wall.

Growing community of inventors

Mountain View, CA, United States of America

Joseph C Deters