Arizona State University

Other

Dignity Health

Joseph Blattman

Louis Schoettle

Hao Yan

Tsafrir Mor

Rachael Sirianni

Xixi Wei

Rebecca Cook

Douglas Grant McFadden

Mohammed Masmudur Rahman

Nancy Yaneth Villa

John Christie

Disclosed herein, in certain embodiments, is a method of inhibiting or treating a cancer with use of a TNF expressing myxoma virus. Also disclosed herein are methods of inhibiting or treating a cancer with use of a mononuclear peripheral blood cells and/or a bone marrow cells treated with a TNF-expressing myxoma virus. Some aspects relate to engineered myxoma virus and pharmaceutical compositions for use with one or more of the methods described herein.

Methods of treating cancer with TNF expressing myxoma virus

Methods for incorporation of unique bowtie-barcodes into a nucleic acid origami nanostructure (FIG.). In particular, provided herein are methods that facilitate pairing and analysis of nucleic acids from individual cells using, for example, high-throughput next-generation sequencing.

High throughput oil-emulsion synthesis of bowtie barcodes for paired mRNA capture and sequencing from individual cells

Disclosed herein are compositions comprising a polypeptide with at least two domains, wherein the first domain is capable of binding CD3 and the second domain is capable of binding to a cancer cell. Also disclosed herein are methods of treating cancer in a subject, comprising: providing a composition comprising a polypeptide with at least two domains, wherein the first domain is capable of binding CD3 and the second domain is capable of binding to a cancer cell; and treating the cancer by administering a therapeutically effective dosage of the composition to the subject.

Antibody fusion protein and related compositions for targeting cancer

Methods for construction of DNA origami nanostructures, as well as for binding, isolation, linking, and deep sequencing information, such as both of TCR alpha and beta CDR3 mRNA, from individual cells within a mixed population of cells without the need for single cell sorting (FIG.).

Methods for obtaining information from single cells within populations using DNA origami nanostructures without the need for single cell sorting

Methods for construction of DNA origami nanostructures, as well as for binding, isolation, linking, and deep sequencing information, such as both of TCR alpha and beta CDR3 mRNA, from individual cells within a mixed population of cells without the need for single cell sorting.

Growing community of inventors

Scottsdale, AZ, United States of America

Joseph Blattman