University of Pennsylvania

Integral Molecular, Inc.

Joseph B Rucker

James A Hoxie

Michael Endres

Robert Doms

Trevor L Hoffman

Paul Bates

John Balliet

Dennis L Kolson

Benjamin J Doranz

Trevor Barnes

Thomas Charpentier

Ross Chambers

Lewis J Stafford

Kimberly-Anne Mattia

Christine R Fisher

Kyle Doolan

Brad Screnci

David F Tucker

The disclosure is directed to an antibody specific for claudin 6 and CD3 and method of preparing and using the same. The present disclosure describes the isolation and characterization of antibodies, antibody fragments, and antibody variants specific for claudin 6 and CD3.

Antibodies directed to claudin 6, including bispecific formats thereof

Antibodies and compositions against GLUT4 and uses thereof are provided herein.

Glucose transporter 4 antibodies, methods of making the same, and uses thereof

Antibodies and compositions against Claudin 6 and uses thereof are provided.

Claudin 6 antibodies and uses thereof

Enveloped virus vectors are described which comprise a cellular virus receptor protein and which are capable of fusing with a cell which comprises a viral envelope protein to which the cellular virus receptor protein is cognate. Enveloped virus vectors comprising a plurality of cellular virus receptor proteins are also described. Methods for making the enveloped virus vectors are described, as are methods of using the enveloped virus vectors. The invention further relates to a lipoparticle comprising a membrane spanning protein, and the lipoparticle can be attached to a sensor surface. The invention relates to methods of producing and using the lipoparticle to, inter alia, assess protein binding interactions.

Method for the production of antibodies that bind to multiple membrane spanning proteins

Method for the preparation of virus-like particles (VLPS) comprising heterologous multiple membrane spanning proteins

Virus-like particles (VLPs) comprising heterologous multiple membrane spanning proteins

Growing community of inventors

Philadelphia, PA, United States of America

Joseph B Rucker