Pharmacia & Upjohn Company

Elan Pharmaceuticals, Inc.

Joseph B Moon

David Louis Brown

John Nicholas Freskos

Varghese John

Yvette M Fobian

Michael B Tollefson

Andrew Simon Bell

Robert Owen Hughes

Dafydd Rhys Owen

Barbara Jagodzinska

Brent V Mischke

Daniel H Rich

Michael John Palmer

E Jon Jacobsen

Shon R Pulley

Todd M Maddux

David Graham Brown

John K Walker

John M Molyneaux

Christopher Phillips

John Jacobs

Steven E Heasley

D Joseph Rogier, Jr

Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I: wherein R, R, Rand Rare as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, synthetic methods, and intermediates are also disclosed.

Pyridine [3,4-b] pyrazinones

The invention relates to substituted piperidine, piperazine, morpholine and thiomorpholine compounds useful in the treatment of Alzheimer's disease and more specifically to compounds that are capable of inhibiting beta-secretase, an enzyme that cleaves amyloid precursor protein to produce amyloid beta peptide (A-beta), a major component of the amyloid plaques found in the brains of Alzheimer's sufferers. One embodiment of the invention relates to compounds having the structure: where Z is CR or N, and R, Rand Rare as described in the specification.

3,4-disubstituted, 3,5-disubstituted and 3,4,5-substituted piperidines

Growing community of inventors

University City, MO, United States of America

Joseph B Moon