Ultima Genomics, Inc.

Joseph Anthony

Nathan Beckett

Jose Martin Sosa

Gilad Almogy

Phillip You Fai Lee

Jacob A Wolf

Nathan Caswell

Stephanie Kubecka

Steven Menchen

Kristopher Barbee

Mark Pratt

Denis Pristinski

Chandan Shee

Gene Polovy

Osip Schwartz

Phillip Lee

Ryan Rosenfeld

Yuto Watanabe

The present disclosure provides methods and processes for increasing the efficiency and accuracy of nucleic acid sequencing using techniques such as polymerase chain reaction (PCR). Methods and systems provided herein may facilitate performing reactions such as emulsion PCR (ePCR) on samples comprising nucleic acids and beads. The methods provided herein may provide a higher throughput compared to existing technologies.

Methods and systems for nucleic acid analysis

Sequencer machine

Provided are systems and methods for analyte detection and analysis. A system can comprise an open substrate. The open substrate may be configured to rotate or otherwise move. The open substrate can comprise an array of individually addressable locations, with analytes immobilized thereto. The substrate may be spatially indexed to identify nucleic acid molecules from one or more sources, and/or sequences thereof, with the respective one or more sources. A solution comprising a plurality of probes may be directed across the array to couple at least one of the plurality of probes with at least one of the analytes to form a bound probe. A detector can be configured to detect a signal from the bound probe via scanning of the substrate while minimizing temperature fluctuations of the substrate or optical aberrations caused by bubbles.

Methods, devices, and systems for analyte detection and analysis

Sample cartridge

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Oakland, CA, United States of America

Joseph Anthony