Pcr Technology Holdings, Lc

Elizabeth Arden, Inc.

US Cosmeceutechs, LLC

Joseph Abernathy Lewis, Ii

Joseph C DiNardo

Andrew S Thompson

James Alan Kerschen

Eberhard Wieland

Falko Diedrich

Birgit Neudecker

Peter C Wade

The present invention relates to cosmetic or dermatological compositions containing PQQ or its esters, methods of treating or promoting skin changes by topical application of these compositions, and methods of synthesis of PQQ esters. The PQQ ester-containing compositions of the present invention are unexpectedly effective in treating skin, particularly with respect to skin tolerance. When included in a topical composition, the PQQ esters of the present invention have an antioxidant effect that is useful in treating a skin change.

Skin treatments containing pyrroloquinoline quinone (PQQ) esters and methods of preparation and use thereof

A double conjugate molecule made of a retinoid, an organic acid, particularly an a-hydroxy acid, and an alcohol or acyl group, is provided which is useful in treating skin conditions, particularly aging. The retinoid, organic acid, and alcohol/acyl group are preferably linked via ester bonds.

Methods for treating of skin conditions with retinoid double conjugate compounds

A method of improving the appearance of skin, involves topically administering to a subject in need thereof a botanical antioxidant composition having a botanical antioxidant extract blend with: (a) at least one hydroxycinnamic acid, and (b) a, and/orextract, wherein the composition is in cream, lotion, solution, serum, anhydrous preparation, emulsion, microemulsion, multiple emulsion, gel, solid stick, ointment, dry powder, spray, or aerosol form.

Methods of preparing and using botanical antioxidant compositions

A botanical antioxidant composition includes a botanical antioxidant extract blend including a first antioxidant botanical extract including at least one hydroxycinnamic acid, and at least one additional antioxidant botanical extracts including at least one antioxidant selected from the group consisting of vitamins, stilbenoids, curcumininoids, tannins, flavones, flavonols, flavan-3-ols, flavanones, anthocyanidins, anthocyanins, isoflavones, flavanonols, proanthocyanidins, dihydroxybenzoic acids, and pyridine alkaloids.

Botanical antioxidant compositions and methods of preparation and use thereof

The present invention relates to novel carboxylic acid-substituted idebenone derivatives, skin treatment compositions containing these carboxylic acid-substituted derivatives, methods of treating skin changes by topical application of these carboxylic acid-substituted idebenone derivatives, and their methods of synthesis. The carboxylic acid-substituted idebenone derivatives of the present invention are unexpectedly effective in treating skin, particularly with respect to skin tolerance. When included in a topical composition, the carboxylic acid-substituted idebenone derivatives of the present invention have an antioxidant effect that is useful in treating a skin change.

Compositions containing carboxylic acid-substituted derivatives

A method for characterizing an oxidative stress protective capacity of an antioxidative substance includes assigning a first score indicative of an oxidative stress protective capacity of a first antioxidative substance. The first score is based on the performance of the first antioxidative substance in a first antioxidative efficacy test relative to the performance of a second antioxidative substance in the first antioxidative efficacy test.

Method for characterizing the oxidative stress protective capacity of an antioxidative substance

The present invention relates to novel carboxylic acid-substituted idebenone derivatives, skin treatment compositions containing these carboxylic acid-substituted idebenone derivatives, methods of treating skin changes by topical application of these carboxylic acid-substituted idebenone derivatives, and their methods of synthesis. The carboxylic acid-substituted idebenone derivatives of the present invention are unexpectedly effective in treating skin, particularly with respect to skin tolerance. When included in a topical composition, the carboxylic acid-substituted idebenone derivatives of the present invention have an antioxidant effect that is useful in treating a skin change.

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Chesterfield, VA, United States of America

Joseph Abernathy Lewis, Ii