Medtronic Ardian Luxembourg S.a.r.l.

Medtronic Adrian Luxembourg S.a.r.l.

Joseph A Traina

Christopher W Storment

Rudy Beasley

Michele Lee Silver

Ayala Hezi-Yamit

Carol M Sullivan

Stefan Stoyanov Tunev

Susan Edwards

Lori Garcia

Provided herein are methods, devices, compositions, and kits for monitoring neuromodulation efficacy based on changes in the level or activity of one or more target biomarkers. One aspect includes a comparison of baseline and post-modulation levels of one or more biomarkers in bodily fluid that have each been collected from a human subject at a relevant time, and that may be used to assess the neuromodulation efficacy. The post-neuromodulation levels for the one or more biomarkers may be collected from the human subject within about 5 minutes to about 14 days post-neuromodulation.

Monitoring of neuromodulation using biomarkers

Provided herein are methods, devices, compositions, and kits for monitoring neuromodulation efficacy based on changes in the level or activity of one or more target biomarkers.

Devices and associated methods for monitoring of neuromodulation using biomarkers

Provided herein are methods, devices, compositions, and kits for monitoring neuromodulation efficacy based on detecting changes in the level or activity of one or more target biomarkers associated with neuromodulation, as well as methods and processes of performing neuromodulation that incorporate monitoring of neuromodulation efficacy based on changes in level or activity of one or more target biomarkers.

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Santa Rosa, CA, United States of America

Joseph A Traina