Ortho Pharmaceutical Corporation

Joseph A Settepani

Robert A Mallory

Michael P Wachter

1-Oxygenated steroids and a method of preparing same as described. The 1-oxygenated steroids are useful as antifertility agents.

1-Oxygenated steroids

Halo steroidal thioketals having a 4-5-membered mono- or dithioketal at the 3-position and a halogen at the 6 and 9 positions are described. The halo thioketals are useful as anti-inflammatory agents.

Halo-steroidal thioketals for treating inflammation

3,5-bis(substituted amino)-1,2,4-dithiazolium salts, 3-substituted amino-5-substituted imino-1,2-4-dithiazolidine salts and dithiobiuret intermediates are administered to male animals to inhibit fertility and to inhibit the growth of, or reduce the size of, the prostate gland and the seminal vesicle.

Method of inducing infertility in male animals and inhibiting the growth

Halo steroidal thioketals having a 4-5 membered mono- or dithioketal at the 3-position and a halogen at the 6 and 9 positions are described. The halo thioketals are useful as anti-inflammatory agents.

Halo-steroidal thioketals

3,5-bis(substituted amino)-1,2,4-dithiazolium salts, 3-substituted amino-5-substituted imino-1,2,4-dithiazolidine salts and dithiobiuret intermediates are administered to male animals to inhibit fertility and to inhibit the growth of, or reduce the size of, the prostate gland and the seminal vesicle.

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Somerville, NJ, United States of America

Joseph A Settepani