The United States Government As Represented by the Department of Veterans Affairs

University of Michigan

Case Western Reserve University

Joseph A Potkay

Jeremy L Dunning

Katherine M Bogie

Steve J A Majerus

Kensall D Wise

Edward T Zellers

Robert W Hower

Changhua Zhan

Richard D Sacks

Robert H Bartlett

Steve Majerus

Katharine T Beach

Masoud Agah

Elyse Fleck

Alvaro Rojas-pena

A microscale collector and injector device comprises a microscale passive pre-concentrator (μPP) and a microscale progressively-heated injector (μPHI). The μPP devices comprises first and second substrate portions, a first collection material, a μPP heater, and an outlet. The first substrate portion defines an array of microscale diffusion channels. The first and second substrate portions cooperate to define a first compartment in fluid communication with the diffusion channels. The first collection material is disposed within the first compartment, at least partially surrounding the outlet. The μPP heater is disposed in thermal communication with the second substrate portion. The μPHI device comprises third and fourth substrate portions, a second collection material, and a plurality of μPHI heaters. The third and fourth substrate portions cooperate to define a second compartment. The second collection material is disposed within the second compartment. The μPHI heaters are disposed in thermal communication with the second compartment.

Microscale collector-injector technologies for passive environmental vapor sampling and focused injection

A sensor apparatus includes at least one substrate layer of an elastically deformable material, the substrate layer extending longitudinally between spaced apart ends thereof. A conductive layer is attached to and extends longitudinally between the spaced apart ends of the at least one substrate layer. The conductive layer includes an electrically conductive material adapted to form a strain gauge having an electrical resistance that varies based on deformation of the conductive layer in at least one direction.

Method for generating one or more strain measurements associated with a biological surface

Disclosed herein are rolled-membrane microfluidic diffusion devices and corresponding methods of manufacture. Also disclosed herein are three-dimensionally printed microfluidic devices and corresponding methods of manufacture. Optionally, the disclosed microfluidic devices can function as artificial lung devices.

Microfluidic diffusion devices and systems, and methods of manufacturing and using same

Provided are photocurable resins comprising a poly(siloxane)-based copolymer together with a photoinitiator, and other optional ingredients such as a photocurable diluent, a photoabsorber, a photosensitizer, or a hydrophillic additive. Also provided are methods of stereolithographically printing a 3-D object from a disclosed resin. Also provided is an improved method for stereolithographically printing a 3-D object, the improvement comprising the use of a disclosed photocurable resin. Further provided is a 3-D microfluidic device such as an artificial lung prepared from a disclosed photocurable resin.

Photocurable resin for high-resolution 3-D printing

An artificial lung system for a patient having a membrane lung system having an gas inlet, a blood inlet, a blood outlet, and an exhaust; a gas system operably coupled to the gas inlet of the membrane lung system; a gas phase COsensor disposed downstream of the exhaust of the membrane lung system and monitoring an exhaust gas CO(EGCO) level and/or an blood oxygen saturation sensor disposed upstream of the blood inlet of the membrane lung system and monitoring a blood oxygen saturation level; and a feedback controller receiving the COsignal and/or blood oxygen saturation signal and outputting a control signal to control gas flow and/or blood flow.

Smart artificial lung and perfusion systems

A microscale collector and injector device comprises a microscale passive pre-concentrator (&#x3bc;PP) and a microscale progressively-heated injector (&#x3bc;PHI). The &#x3bc;PP devices comprises first and second substrate portions, a first collection material, a &#x3bc;PP heater, and an outlet. The first substrate portion defines an array of microscale diffusion channels. The first and second substrate portions cooperate to define a first compartment in fluid communication with the diffusion channels. The first collection material is disposed within the first compartment, at least partially surrounding the outlet. The &#x3bc;PP heater is disposed in thermal communication with the second substrate portion. The &#x3bc;PHI device comprises third and fourth substrate portions, a second collection material, and a plurality of &#x3bc;PHI heaters. The third and fourth substrate portions cooperate to define a second compartment. The second collection material is disposed within the second compartment. The &#x3bc;PHI heaters are disposed in thermal communication with the second compartment.

Sensor apparatus and method of making same

Conductive layer formed strain gauge and method of making same

A microvalve device includes a semiconductor-based valve housing that defines a flow passage, and a valve face disposed within the valve housing and in fluid communication with the flow passage. The microvalve device further includes a thermal expansion actuator that drives movement of the valve face from a first position to a second position relative to the flow passage, and a capacitor that holds the valve face in the second position. The microvalve may also include an insulating layer disposed on portions of the semiconductor-based valve housing, and a capacitance sensor for monitoring a capacitance level to determine when the valve face reaches the second position. Once the sensor indicates that the second position has been reached, power is no longer applied to the thermal expansion actuator such that power is only substantially consumed during the transition from the first position to the second position. The thermal expansion actuator may include a heating element and a thermal expansion substance for thermopneumatic displacement of the valve face.

Thermopneumatic microvalve

A high-sensitivity, separation microcolumn assembly for a microgas chromatograph and the like is provided. The assembly has an ultra-low mass complete with integrated heaters. The assembly uses multiple zones for temperature control, and microstructures that permit very rapid heating and cooling of the microcolumn.

Growing community of inventors

Plymouth, MI, United States of America

Joseph A Potkay