Leland Stanford Junior University

Dana-farber-cancer Institute Inc.

Joseph A Mollick

Paul J Utz

Pearline Teo

Glenn Dranoff

F Stephen Hodi

Jan Schmollinger

The present invention provides novel IgE antibodies useful for inhibiting or preventing metastatic cancer. Also provided are methods to inhibit tumor metastasis by modulating the activity of at least one non-tumor cell, treating a patient to inhibit or prevent tumor metastases of a primary solid tumor, treating metastatic carcinoma, reducing metastasis of carcinoma cells, and reducing the growth kinetics of a primary solid tumor or a metastasized cell or tumor.

IgE antibodies for the inhibition of tumor metastasis

The invention features tumor antigens; tumor antigen-encoding nucleic acids; antibodies specific for tumor antigens and methods of using the antibodies; methods of identifying tumor antigens and the nucleic acids that encode them; methods of monitoring or diagnosing tumors in patients; methods of testing patients for the increased likelihood of developing a tumor; and methods and compositions for treatment of a tumor or prophylaxis against developing a tumor.

Tumor antigens and uses thereof

Growing community of inventors

Palo Alto, CA, United States of America

Joseph A Mollick