Merck Frosst Canada, Inc.

Merck Frosst Canada & Co.

Karolinska Innovations Ab

Merck + Co., Inc.

Joseph A Mancini

Gary P O'Neill

Philip J Vickers

Brian P Kennedy

Bengt Samuelsson

Per-Johan Jakobsson

Ralf Morgenstern

Anthony Ford-Hutchinson

Wanda A Cromlish

Elizabeth Wong

Cheuk K Lau

Cameron Black

Petpiboon Prasit

David Claveau

Denis Riendeau

The invention discloses a human cyclooxygenase-2 cDNA, a human cyclooxygenase-2 and assays for preferentially and independently measuring cyclogenase-2 or cyclooxygenase-1 activity present in a given sample.

Human cyclooxygenase-2 cDNA and assays for evaluating cyclooxygenase-2 activity

Isolated PGE synthase, provided from encoding nucleic acid. Methods of production and use. Assays for modulators, especially inhibitors, of PGE synthase activity.

Methods and means for modulating PGE synthase activity

The invention discloses a cDNA consisting of human cyclooxygenase-2 cDNA attached to 3&prime; flanking sequence of human cyclooxygenase-1 methods for increasing the expression of human cyclooxygenase-2 in transformed cells and assays for preferentially and independently measuring cyclogenase-2 in samples.

High level expression of human cyclooxygenase-2

The present invention relates to a whole cell assay for cathepsin K. The present invention is useful for determining cathepsin K activity in a mammalian cell systems and for identifying and evaluating inhibitors of cathepsin K.

Whole cell assay for cathepsin K activity

Human cyclooxygenase-2 cDNA and assays for evaluating cyclooxygenase-2

Compounds of the structures shown below are specific inhibitors of cyclooxygenase-2 useful in the treatment of cyclooxygenase-2 mediated disease states such as inflammation, pain and fever, and are non-ulcerogenic. ##STR1##

1-aroyl-3-indolyl alkanoic acids and derivatives thereof useful as

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St. Leonard, Canada

Joseph A Mancini