Sio2 Medical Products, Inc.

Si02 Medical Products, Inc.

Joseph A Jones

Thomas E Fisk

Christopher Weikart

John Thomas Felts

Robert S Abrams

John Belfance

Peter J Sagona

Becky L Clark

Adam Stevenson

Steven J Martin

Brian Russell Lilly

James Troy Gresham

Matthew Wills

A method and apparatus for plasma modifying a workpiece such as a medical barrel, medical barrel, vial, or blood tube is described. Plasma is provided within the lumen of the workpiece. The plasma is provided under conditions effective for plasma modification of a surface of the workpiece. A magnetic field is provided in at least a portion of the lumen. The magnetic field has an orientation and field strength effective to improve the uniformity of plasma modification of the generally cylindrical interior surfaceof the generally cylindrical interior surface

Controlling the uniformity of PECVD deposition on medical syringes, cartridges, and the like

An apparatus and methods for testing the integrity of a barrier coating on a vessel. An off gas test fixture includes a face seal positioned about an opening of the vessel. A side seal is positioned about a portion of the vessel's wall and separated from the face seal by a space. Additionally, a cover may be secured to the fixture that encompasses an interface portion of the fixture and the vessel. Before and/or during testing, gas in the space between the side and face seals may be evacuated, as well as gas present in an interior area of the vessel. The vessel may be exposed to test gas(es) that is soluble by the plastic material of the vessel before and/or after being secured to the fixture. During testing, test gas(es) desorbed by the vessel may be evacuated, with the molecular flow being measured using a mass extraction unit.

Method and apparatus for detecting rapid barrier coating integrity characteristics

A method for coating a substrate surface such as a syringe part by PECVD is provided, the method comprising generating a plasma from a gaseous reactant comprising an organosilicon precursor and optionally an oxidizing gas by providing plasma-forming energy adjacent to the substrate, thus forming a coating on the substrate surface by plasma enhanced chemical vapor deposition (PECVD). The plasma-forming energy is applied in a first phase as a first pulse at a first energy level followed by further treatment in a second phase at a second energy level lower than the first energy level. The lubricity, hydrophobicity and/or barrier properties of the coating are set by setting the ratio of the Oto the organosilicon precursor in the gaseous reactant, and/or by setting the electric power used for generating the plasma.

PECVD lubricity vessel coating, coating process and apparatus providing different power levels in two phases

An article is described including an article surface, a primer coating or layer of SiOx, SiOCor SiNCapplied to the article surface, and a deposit of lubricant applied to the primer coating or layer. The primer coating or layer of SiO, SiOCor SiNCis applied by chemical vapor deposition of a polysiloxane or polysilazane precursor in the presence of oxygen. A first deposit of lubricant is applied to the primer coating or layer. The primer coating or layer improves the adhesion or wetting of the lubricant on the surface to be lubricated. Examples of such an article are a prefilled syringe having a barrel with a lubricated interior portion and a plunger tip that slides along it. Another example of such an article is a vial having a lubricated opening to receive a septum. Another aspect of the invention is a method of making such an article.

Plasma or CVD pre-treatment for lubricated pharmaceutical package, coating process and apparatus

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Birmingham, AL, United States of America

Joseph A Jones