Waters Technologies Corporation

Waters Investments Limited

Millipore Corporation

Micromass UK Limited

Joseph A Jarrell

Michael John Tomany

Douglas P Wittmer

Wade P Leveille

Craig A Dorschel

Michael O Fogwill

Pamela Carmen Iraneta

Guo-Zhong Li

Edouard S P Bouvier

Joseph A Luongo

Michael R Jackson

Stanislaw Koziol

Theodore D Ciolkosz

David M Strand

Michael J Tomany

Daniel James Kenny

Joseph D Michienzi

Geoff C Gerhardt

Marc Victor Gorenstein

Theodore A Dourdeville

David Gordon

Ross Clark Willoughby

James Usowicz

Bernard Bunner

Keith Fadgen

Martin Gilar

Jonathan L Belanger

Edward William Sheehan

Moon Chul Jung

Abhijit Tarafder

Ian David Trivett

Stephen O'Brien

Stephen C Gabeler

John Angelosanto

Neal B Almeida

Christopher Seith

Thomas S McDonald

Xiangjin Song

Lucas O Tiziani

Joseph Kareh

Patrick Brophy

Peter Pino

LeRoy B Martin

Alistair J Schofield

Fabrice Gilles Ernest Gritti

Edouard Sp Bouvier

Edouard SP Bouvier

An image charge detection assembly for a mass spectrometer comprising an image charge detector that is housed within an electrically conductive shielding enclosure, and a preamplifier, wherein at least an input stage of the preamplifier, which is electrically connected to the detector, is housed with the detector within the enclosure.

Inductive detector with integrated amplifier

An ion detector comprises a surface configured to receive one or more ions and a detector configured to detect one or more ions by detecting electromagnetic radiation scattered by one or more ions at the surface.

Ion detector

An apparatus for performing liquid chromatography includes a chromatography column, and an insulating member surrounding the chromatography column wherein the insulating member is formed from a vacuum chamber surrounding the chromatography column. Another apparatus for performing liquid chromatography includes a chromatography column, and an insulating member surrounding the chromatography column, wherein the insulating member includes aerogel. Also described is a method of insulating a chromatography column comprising forming a jacket surrounding the chromatography column, and creating a vacuum chamber in an area between the jacket and the chromatography column.

Techniques for thermally insulating a liquid chromatographic column

A method of mass spectrometry is disclosed comprising focusing electromagnetic radiation into a region of a liquid samplebelow a surface of the liquid sample so as to generate one or more bubbles. The one or more bubblesrise to the surface of the liquid whereupon one or more droplets of liquidare emitted from the surface of the liquid sample. The method further comprises directing the one or more emitted dropletstowards an inlet of a mass spectrometer

Apparatus and method for contactless sampling of solutions and interface to mass spectrometry

Apparatus and methods for performing chromatography may include a chromatography column and a vacuum insulated jacket having an inner wall and an outer wall. A vacuum area may be formed between the inner wall and the outer wall. The inner wall of the vacuum insulated jacket may surround the chromatography column. A gap may be formed between an outer wall of the chromatography column and the inner wall of the vacuum insulated jacket. The vacuum insulated jacket may extend beyond one or more end frits of the column. The gap may be filled with one or more materials so as to form an insulating or thermal barrier.

Techniques for thermally insulating a chromatographic column

Systems, methods, and devices for detecting leaks in chromatography systems are disclosed. The leak detection system includes a sealable compartment disposed to surround at least one component of a chromatography system. The detector is in communication, e.g., fluid communication, with an interior of the sealable compartment and configured to detect the leak by various mean including the presence of liquid or the presence of vapor, or both within the sealable compartment.

Systems, methods, and devices for detecting leaks in a chromatography system

An ion inlet assembly for connecting to a mass spectrometer housing is disclosed comprising a sampling limiting body having a sampling orifice. The sampling limiting body comprises a nickel disk wherein the disk and sampling orifice are made or formed by an electroforming process.

Ion inlet assembly

A method and apparatus for analyzing a response of a cellular entity to a component of interest are described. The cellular entity may be a cell or an organoid. The method includes processing a heterogeneous population of cellular entities that are combined with the component of interest. An entity flow containing the cellular entities is generated. A morphological image of a portion of the entity flow having a cellular entity is acquired and the cellular entity is identified as belonging to an entity class. The entity flow is provided to a mass spectrometer system that performs an analysis of the cellular entity. The mass spectrometer analysis of the cellular entity can be correlated with the identified entity class. Alternatively, portions of the entity flow are deposited as samples on a sample plate and the mass spectrometer analysis is performed offline, for example, using an ionization process with each sample.

Method and system for screening of cells and organoids

The present disclosure relates to methodologies, systems and apparatus for controlling pressure in a CO-based chromatography system. A first COpump operates in constant flow mode and delivers COto a chromatography column, and liquid modifier is introduced to the chromatography column according to a gradient. A second COpump is disposed downstream of the column and operates in constant pressure mode to introduce COinto a flow stream at an output of the column. Liquid modifier is also introduced into the flow stream at the output of the column according to a reverse gradient compared to the gradient entering the chromatography column.

Carbon dioxide based chromatography systems including multiple carbon dioxide pumps

An ion source is disclosed that alternates between ionizing analytes in a sample by electrospray ionization and impact ionization.

Dual mode ionization device

An interface for a mass spectrometer system is provided. The interface can include an inner ceramic tube fabricated from a first ceramic material and an outer tube fabricated from a second ceramic material surrounding the inner ceramic tube. The inner ceramic tube can have high electrical resistivity and high thermal conductivity and the intermediate ceramic tube can have an electrical resistivity that is at least an order of magnitude higher than the electrical resistivity of the first ceramic material and a thermal conductivity that is at least an order of magnitude higher than the thermal conductivity of the first ceramic material.

Atmospheric interface for electrically grounded electrospray

A method includes passing a mobile phase fluid flow comprising liquefied CO2 through a separation column; then introducing a makeup fluid flow into the mobile phase fluid flow to form a mixed fluid flow; and then splitting the mixed fluid flow.

Flow splitting in supercritical fluid chromatography systems

A method of ionizing a sample includes providing an aqueous liquid and directing a jet comprising carbon dioxide to interact with the provided aqueous liquid. One or both of the aqueous liquid and the jet comprise the sample. At least a portion of the sample is ionized due to the interaction.

Method and an apparatus for ionizing a sample

Embodiments of the present invention feature devices and methods for performing mass analysis. One embodiment of the device comprises an inlet housing for mounting on the first wall between the area of low pressure and the area of high pressure. The inlet housing has passages and restrictions which can be adjusted with respect to a sample plume or changed by substituting alternative inlet housings.

Devices and methods for performing mass analysis

Growing community of inventors

Newton Highlands, MA, United States of America

Joseph A Jarrell