Seattle Genetics, Inc.

Other

Joseph A Francisco

Alan F Wahl

Clay B Siegall

Henry Perry Fell, Jr

George Georgiou

Young H Jang

Grant Risdon

Charles F Earhart

Henry P Fell

The present invention relates to methods and compositions for the prevention and treatment of cancer, inflammatory diseases and disorders or deficiencies of the immune system. The methods of the invention comprise administering a CD40 binding protein that potentiates the binding of CD40 to CD40 ligand.

Methods for augmenting an immune response using anti-CD40 antibodies

Methods for the treatment of cancer using anti-CD40 antibodies

Methods for treating immune disorders or cancer with anti-CD40 antibodies

The present invention relates to methods and compositions for the treatment of Hodgkin's Disease, comprising administering proteins characterized by their ability to bind to CD30, or compete with monoclonal antibodies AC10 or HeFi-1 for binding to CD30, and exert a cytostatic or cytotoxic effect on Hodgkin's Disease cells. Such proteins include derivatives of monoclonal antibodies AC10 and HeFi-1. The proteins of the invention can be human, humanized, or chimeric antibodies; further, they can be conjugated to cytotoxic agents such as chemotherapeutic drugs. The invention further relates to nucleic acids encoding the proteins of the invention. The invention yet further relates to a method for identifying an anti-CD30 antibody useful for the treatment or prevention of Hodgkin's Disease.

Recombinant anti-CD30 antibodies and uses thereof

Recombinant anti-CD40 antibody and uses thereof

Methods for the treatment and prevention of cancer using anti-CD40 antibodies

Nucleic acids encoding anti-CD40 proteins and methods of producing recombinant anti-CD40 proteins

The invention relates to a method for producing stable, surface-expressed polypeptides from recombinant gram-negative bacterial cell hosts. A tripartite chimetic gene and its related recombinant vector include separate DNA sequences for directing or targeting and translocating a desired gene product from a cell periplasm to the external cell surface. A wide range of polypeptides may be efficiently surface expressed, including .beta.-lactamase and alkaline phosphatase. Full enzyme activity is maintained and the proteins remain anchored to the bacterial outer membrane surface.

Expression of proteins on bacterial surface

A valve is disclosed herein having an open-ended passageway with a movable gate inbetween its opposite ends for selectively opening and closing the passageway. The opposite valve ends defining the passageway include a threaded fitting or cap carried on a valve body defining a tapered gland occupied by a frustro-conical resilient seal cooperating with the gland to seal between a conduit and the valve body. The valve body is adapted for installation in a situation joining opposing ends of separated conduit or pipes.

Gate valve

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Edmonds, WA, United States of America

Joseph A Francisco