The State University of New York

Therex Technologies, Inc.

Joseph A Dunn

Robert A Coburn

Richard T Evans

Robert J Genco

Robert A Genco

A method of treating chronic inflammation in a mammal is disclosed which comprises contacting the affected area with an amount sufficient to ameliorate the inflammatory condition, of a compound of the following formula: ##STR1## wherein Z is a substituted phenyl ring, R is an alkylsulfonyl group of 1-20 carbon atoms, and X is selected from the group consisting of --CN, --NO.sub.2, --H, halogen, lower alkyl and lower haloalkyl.

Method of relieving chronic inflammation by using

A method of treating inflammation in a mammal, which comprises contacting the affected area with an amount sufficient to ameliorate the inflammatory condition, of a compound of the following formula ##STR1## in a pharmaceutically acceptable carrier containing a detergent, where Z is a substituted phenyl, R is a substituted or unsubstituted alkylsulfonyl group from 1 to 20 carbon atoms and X is --CN, --NO.sub.2, --H, halogen, lower alkyl or lower haloalkyl radical.

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Amherst, NY, United States of America

Joseph A Dunn