Laboratorios Ojer Pharma, S.l.

Josep Ramon Ticó Grau

Josep Maria Suñé Negre

Carlos González Ojer

Montserrat Miñarro Carmona

Encarna García Montoya

Pilar Pérez Lozano

Raquel Maria Da Costa Martins

Manel Roig Carreras

Natalia Sánchez Porqueres

Josep M Suñé Negre

The present invention provides a gel combination comprising: polycarbophil in an amount comprised from 1 to 5% by weight; polyvinylpirrolidone in an amount comprised from 4 to 8% by weight; glycerine in an amount comprised from 1 to 10% by weight; and propyleneglycolin an amount comprised from 20 to 40% by weight; wherein: the weight ratio between polyvinylpirrolidone:polycarbophil is comprised between 1:1 and 4:1, the weight ratio between glycerine:polycarbophil is comprised from 0.5:1 to 2:1, and the weight ratio propyleneglycol:polycarbophil is comprised from 8:1 to 20:1. The invention also provides transparent compositions comprising such gel combinations as well as processes for their preparation and the use thereof as a medicament. Due to the specific excipients, % by weight, and weight ratios forming the combination, the resulting compositions show a high bioadhesivity and bioavailability of the active ingredient, without toxic adverse effects.

Gel compositions

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Barcelona, Spain

Josep Ramon Ticó Grau