Som Innovation Biotech, S.l.

Laboratorios Ojer Pharma, S.l.

Vitae Natural Nutrition, S.l.

Josep Maria Suñé Negre

Raúl Insa Boronat

Núria Reig Bolaño

Santiago Esteva Gras

Montserrat Miñarro Carmona

Carlos González Ojer

Oscar Huertas Gambín

Anna Nardi Ricart

Gal-la Pericot Mohr

Natalia Sánchez Porqueres

Raimon Cortada Pasola

Josep Ramon Ticó Grau

Manuel Roig Carreras

Manel Roig Carreras

Encarna García Montoya

Rocio Sarrate Arjona

Raquel Maria Da Costa Martins

Pilar Pérez Lozano

The present invention relates to sustained release tablet comprising micronized tolcapone, a release retardant and a binder, to said tablet for use in the prevention and/or treatment of a transthyretin-associated amyloidosis, to a method for the prevention and/or treatment of a transthyretin-associated amyloidosis comprising administering to a subject in need thereof an effective amount of said tablet, to pharmaceutical composition in the form of said tablet which is used in the prevention and/or treatment of a transthyretin-associated amyloidosis and to a process for the manufacture of said tablet.

Sustained release compositions comprising micronized tolcapone

The present invention provides a gel combination comprising: polycarbophil in an amount comprised from 1 to 5% by weight; polyvinylpirrolidone in an amount comprised from 4 to 8% by weight; glycerine in an amount comprised from 1 to 10% by weight; and propyleneglycolin an amount comprised from 20 to 40% by weight; wherein: the weight ratio between polyvinylpirrolidone:polycarbophil is comprised between 1:1 and 4:1, the weight ratio between glycerine:polycarbophil is comprised from 0.5:1 to 2:1, and the weight ratio propyleneglycol:polycarbophil is comprised from 8:1 to 20:1. The invention also provides transparent compositions comprising such gel combinations as well as processes for their preparation and the use thereof as a medicament. Due to the specific excipients, % by weight, and weight ratios forming the combination, the resulting compositions show a high bioadhesivity and bioavailability of the active ingredient, without toxic adverse effects.

Gel compositions

New dietary supplement composition comprising, as active ingredients:

Nutritional supplement composition

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Barcelona, Spain

Josep Maria Suñé Negre