Warner-lambert Company

Josefino B Tunac

James C French

Gerard C Hokanson

John P Schaumberg

Blanche D Graham

Timothy R Hurley

Richard H Bunge

Tim A Smitka

Christopher Franklin Bigge

Edward Faith Elslager

John H Wilton

Cynthia A Young

William E Dobson

Suresh S Stampwala

Marjorie A Underhill

Stephen W Mamber

A purified isolate of an actinomycete identified as ATCC 39366 is capable of producing the anti-microbial compound CL-1957B which also exhibits antitumor properties. The antimicrobial compound CL-1957B is produced by cultivating isolate ATCC 39366 under aerobic conditions in a culture medium containing assimilable sources of carbon and nitrogen until a substantial quantity of the CL-1957B compound is produced, and subsequently isolating the compound. The antibiotic compound CL-1957B, its pharmaceutically acceptable salts, the pharmaceutical compositions comprising this substance together with a pharmaceutically acceptable carrier is also disclosed, as are methods of treating microbial infections and tumors in mammals, employing these pharmaceutical compositions.

CL-1957B antibiotic compound and its production

A purified isolate of an actinomycete identified as ATCC 39366 is capable of producing the anti-microbial compound CL-1957A which also exhibits antitumor properties. The antimicrobial compound CL-1957A is produced by cultivating isolate ATCC 39366 under aerobic conditions in a culture medium containing assimilable sources of carbon and nitrogen until a substantial quantity of the CL-1957A compound is produced, and subsequently isolating the CL-1957A compound. The antibiotic compound CL-1957A and pharmaceutical compositions comprising this substance together with a pharmaceutically acceptable carrier is also disclosed, as are methods of treating microbial infections and tumors in mammals, employing these pharmaceutical compositions.

CL-1957A antibiotic compound

Acids, esters, imine acids, imine esters, and imine amides derived from 6-formyl-4,7,9-trihydroxy-1-phenazinecarboxylic acid, methyl ester and from 6-formyl-4,7,9-trihydroxy-8-methyl-1-phenazinecarboxylic acid, methyl ester demonstrate anti-microbial and antineoplastic activity. A purified strain of Streptomyces galanosa, NRRL 15738, is capable of producing 6-formyl-4,7,9-trihydroxy-8-methyl-1-phenazinecarboxylic acid, methyl ester in isolable quantities from a fermentation broth containing assimilable sources of carbon and nitrogen.

Purified culture of streptomyces galanosa

A strain of Actinomadura sp., NRRL 15758, is capable of producing the CL-1724 complex of antibiotic substances in isolable quantities under conditions of aerobic fermentation in a culture medium containing assimilable sources of carbon and nitrogen.

Antibiotic-producing microorganism culture

2'-Chloropentostatin is a potent inhibitor of the enzyme adenosine deaminase and possesses utility as an agent for potentiating the activity of antiviral agents for the treatment of DNA viruses which agents contain an adenine moiety, such as 9-(beta-D-arabinosyl)adenine. A pure strain of actinomycete, designated ATCC 39365 which is capable of producing 2'-chloropentostatin, a method of producing 2'-chloropentostatin by aerobic fermentation, and pharmaceutical compositions including 2'-chloropentostatin are also disclosed.

2-chloropentostatin compound having adenosine diaminase inhibitory

Acids, esters, imine acids, imine esters, and imine amides derived from 6-formyl-4,7,9-trihydroxy-1-phenazinecarboxylic acid, methyl ester and from 6-formyl-4,7,9-trihydroxy-8-methyl-1-phenazinecarboxylic acid, methyl ester demonstrate antimicrobial and antineoplastic activity. A purified strain of Streptomyces galanosa, NRRL 15738, is capable of producing 6-formyl-4,7,9-trihydroxy-8-methyl-1-phenazinecarboxylic acid, methyl ester in isolable quantities from a fermentation broth containing assimilable sources of carbon and nitrogen.

Antimicrobial and antitumor phenazine carboxaldehydes and derivatives

A purified isolate of Actinomadura verrucaspora subspecies veractimycin is capable of producing a complex of sulfur-containing antibiotic compounds having anti-tumor activity in recoverable amounts when cultivated under aerobic conditions in a culture medium containing assimilable sources of carbon, nitrogen, and sulfur.

Purified culture of Actinomadura verrucaspora subspecies veractimyces

Novel phosphorus containing antibiotic compounds that are antitumor agents designated CL 1565-A, CL 1565-B, CL 1565-T and their salts, a process for the production and the method of using said compounds, and pharmaceutical compositions containing various salts of the compounds of the invention alone or in combination with other antitumor agents in the treatment of microbial infections and neoplastic diseases, are provided.

CL 1565 antibiotic compounds

A strain of actinomycete, NRRL 15758, is capable of producing the CL-1724 complex of compounds under conditions of aerobic fermentation in the presence of assimilable sources of carbon and nitrogen. The compound CL-1724B-2 exhibiting antimicrobial and antitumor activity, is claimed together with pharmaceutical compositions and methods of treating microbial infections and tumors in mammals employing these pharmaceutical compositions.

CL-1724 Antibiotic compounds, their production and use

A purified isolate of an actinomycete identified as ATCC 39363 is capable of producing a complex of sulfur-containing antibiotic compounds having activity against transplanted tumors. Antibiotic compounds CL-1577A and CL-1577B and their closely related congeners are produced by cultivating isolate ATCC 39363 under aerobic conditions in a culture medium containing assimilable sources of carbon and nitrogen until a substantial quantity of the CL-1577 complex is produced, and subsequently isolating the complex or one or more of the compounds. The antibiotic compounds CL-1577A, CL-1577B, their congeners, and pharmaceutical compositions comprising these substances together with a suitable carrier are also disclosed.

CL-1577 Antibiotic compounds and their production

A biologically pure culture of the microorganism Streptomyces pulveraceus subspecies fostreus ATCC 31906 is provided. Strain 31906 is capable of producing the CL 1565 antibiotic complex in a recoverable quantity upon cultivation in an aqueous nutrient medium containing assimilable sources of nitrogen and carbon. The CL 1565 antibiotic complex includes CL 1565-A, -B and -T sodium salt compounds that in dosage form are useful antibiotics and antitumor agents.

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Troy, MI, United States of America

Josefino B Tunac