Clin Midy

Josef Schmitt, Deceased

Intermediates for preparing novel benzodiazepines having the formula ##SPC1## In which R.sub.1 is a hydrogen or halogen atom or a trifluoromethyl, loweralkyl, loweralkoxy, nitro or amino group; R.sub.2 is a furyl, a thienyl, cyclohexyl, a loweralkyl group or a phenyl group which may be substituted by a halogen atom or by a trifluoromethyl, nitro, loweralkoxy or loweralkyl group; and R.sub.3 is a hydrogen atom or a loweralkyl group; and R.sub.4 is lowercarbalkoxy, carbamoyl, N-loweralkylcarbamoyl, N,N-diloweralkylcarbamoyl, N-(diloweralkylaminoalkyl)carbamoyl, a group having the formula --COOCat in which Cat is a cation of an alkali metal or a semication of an alkaline earth metal or COOCat.CatOH, said intermediates being ortho-aminoaryl ketimines having the formula ##SPC2## Wherein R is hydrogen or ##EQU1## R.sub.1, R.sub.2, and R.sub.3 are as defined above, R.sub.4 is a hydrogen atom, a lowercarbalkoxy, carbamoyl, N-loweralkylcarbamoyl, N,N-diloweralkylcarbamoyl, N-(diloweralkylaminoalkyl)-carbamoyl, alkyl or substituted alkyl group; and R.sub.5 is a loweralkyl group.

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LATE OF L'Hay-les-Roses, France

Josef Schmitt, Deceased