Boehringer Ingelheim Gmbh

Dr. Karl Thomae Gmbh

Dr. Karl Thomae Gesellschaft MIT Beschrankter Haftung

Karl Thomae Gmbh

Josef Roch

Erich Muller

Berthold Narr

Josef Nickl

Walter Haarmann

Johannes M Weisenberger

Rainer Zimmermann

Armin Heckel

Wolfgang Schroter

Laurence A Harker

Hans W Schroter

Johannes-Maximilian Weisenberger

Compounds of the formula ##STR1## wherein R.sub.1 is a substituted alkoxy group, or an optionally substituted mercapto or amino group,

2-(perhydro-1,4-diazino)-pyrimido[5,4-d]-pyrimidines and salts thereof

The invention relates to new compounds of general formula ##STR1## wherein R.sub.1 represents an alkyl group,

8-alkylthio-2-piperazino-pyrimido[5,4-d]-pyrimidines

2-(Perhydro-1,4-diazino)-pyrimido(5,4-D)-pyrimidines, pharmaceutical

The present invention relates to novel indolinones of the general formula ##STR1## wherein R represents an aryl group having from 6 to 10 carbon atoms, unsubstituted or mono- or disubstituted by alkyl groups having from 1 to 5 carbon atoms, hydroxyl groups, alkoxy groups having from 1 to 3 carbon atoms, or halogen atoms, whereby the substituents may be the same or different and whereby the phenyl nucleus of the aryl group may also be substituted by an amino group, a hydroxyl group, or an alkanoylamino group with altogether from 1 to 3 carbon atoms; an aryl group having from 6 to 10 carbon atoms, substituted by 3 or 4 alkyl groups having from 1 to 5 carbon atoms each; a phenyl group substituted by a phenyl, halogenphenyl, or cycloalkyl group with 5 to 7 carbon atoms; an aralkyl group having from 7 to 11 carbon atoms; or a pentamethylphenyl, pyridyl, or quinolyl group; m represents the number 0, 1, or 2; and n represents the number 2, 3, 4, 5, or 6.

Indolinones and pharmaceutical compositions containing same

Compounds of the formula ##STR1## wherein R.sub.1 is phenylalkylamino, alkylamino, dialkylamino, piperidino, morpholino, thiomorpholino or 1-oxido-thiomorpholino;

2-Piperazino-pteridines useful as antithrombotics and antimetastatics

Compounds of the formula ##STR1## wherein n is 0 or 1;

Antithrombotic sulfoximino carbostyrils

Antithrombotic use of 2-(perhydro-1,4-diazino)-pyrimido

This invention is directed to novel benzoxazin-2-ones of the formula ##STR1## wherein A is a sulfur atom or an SO, SO.sub.2, R--N.dbd.S, or R--N.dbd.SO.sub.2 group where R is a hydrogen atom or an acyl group;

Substituted benzoxazin-2-ones and pharmaceutical compositions containing

Compounds of the formula ##STR1## wherein R.sub.1 is optionally substituted alkyl;

Trisubstituted pyrimido[5,4-d]pyrimidines and salts thereof

Antithrombotic sulfimino and sulfoximino indolinones-2

Compounds of the formula ##STR1## wherein W is vinylene, methyl-vinylene, methylene or ethylene;

Cardiotonic and antithrombotic sulfur-containing derivatives of

Compounds of the formula ##STR1## wherein R.sub.1 is unsubstituted, mono-substituted or di-substituted piperidino, where the substituents are selected from the group consisting of methyl, hydroxymethyl, hydroxyl, phenyl and benzyl;

3-Amino-4-phenyl-6-piperidino-1H-pyrazolo[3,4-b]-pyridines and salts

Compounds of the formula ##STR1## wherein R.sub.1 is unsubstituted, mono-substituted or di-substituted thiomorpholino, where the substituents are selected from the group consisting of methyl, hydroxymethyl, hydroxyl, phenyl and benzyl;

3-Amino-4-phenyl-6-thiomorpholino-1H-pyrazolo-[3,4-b]pyridines and salts

Pharmaceutical dosage unit compositions containing, as a combination of active ingredients, dipyridamole and sulfinpyrazone, and a method of using the same as antithrombotics.

Antithrombotic pharmaceutical compositions containing dipyridamole and

Compounds of the formula ##STR1## wherein R.sub.1 is mono- or di-substituted amino, where the substituents are selected from the group consisting of alkyl of 1 to 6 carbon atoms, cyclohexyl, allyl and benzyl; unsubstituted, mono-substituted or di-substituted pyrrolidino, piperidino, hexamethyleneimino, morpholino, piperazino, thiomorpholino, 1-oxido-thiomorpholino or 1,1-dioxido-thiomorpholino, where the substituents are selected from the group consisting of methyl, hydroxymethyl, hydroxyl, phenyl and benzyl; 1,2,5,6-tetrahydropyridino; 1,2,3,4-tetrahydroisoquinolino; indolino; or 3,6-ethylene-hexamethyleneimino;

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Biberach, Germany

Josef Roch