Boehringer Ingelheim Gmbh

Dr. Karl Thomae Gmbh

Dr. Karl Thomae Gesellschaft MIT Beschrankter Haftung

Karl Thomae Gmbh

Celamerck Gmbh & Co. Kg

Josef Nickl

Erich Muller

Berthold Narr

Walter Haarmann

Josef Roch

Johannes M Weisenberger

Armin Heckel

Wolfhard Engel

Ernst Seeger

Helmut Teufel

Wolfgang Eisert

Thomas Muller

Gunther Engelhardt

Wolfgang Schroter

Helmut Pieper

Jurgen Curtze

Rainer Zimmermann

Sigmund Lust

Rudolf Kadatz

Christo A Drandarevski

Norbert Hauel

Volkhard Austel

Joachim Heider

Guido Albert

Gunter Trummlitz

Manfred Reiffen

Willi Diederen

Ludwig Schroder

Heinz-Manfred Becher

Jacobus C Van Meel

Helmut Ballhause

Benthold Narr

Johannes-Maximilian Weisenberger

The invention relates to new sulphonamidoethyl compounds having valuable pharmacological properties, particularly anti-thrombotic properties, and which are also thromboxane antagonists.

Sulphonamidoethyl compounds and pharmaceutical compositions comprising

The invention relates to new benzenesulphonamidoindanyl compounds useful in the treatment and prophylaxis of thromboembolic diseases, arteriosclerosis and tumor metastasis.

Benzenesulphonamidoindanyl compounds

Compounds of the formula ##STR1## wherein A is ##STR2## B is ##STR3## R.sup.1 is hydrogen; halogen, cyano or optionally substituted C.sub.1-4 alkyl; and

Acrylic acid morpholides, fungicidal compositions and use

The invention relates to new sulphonamido-ethyl compounds having the following structure: ##STR1## wherein R.sub.1 is substituted or unsubstituted phenyl, benzyl, nitrophenyl, acetamidophenyl or thienyl, R.sub.2 is hydroxycarbonyl or alkoxycarbonyl bonded via alkylene or alkenylene, or a 4,5-dihydro-pyridazin-3-one-6-yl or pyridazin-3-on-6-yl group optionally substituted on a ring carbon by C.sub.1 -C.sub.3 alkyl and X is substituted or unsubstituted imino, oxygen or sulphur, which compounds may be used to prevent arteriosclerosis or tumor metastasis, and are antitrombotic and thromboxane antagonists.

Sulphonamidoethyl compounds, pharmaceutical compositions comprising

The invention relates to new benzenesulphonamidoindanyl compounds having the following formula ##STR1## wherein the substituents are defined herein useful in the treatment and prophylaxis of thromboembolic diseases, arteriosclerosis and tumor metastasis.

Benzenesulphonamidoindanyl compounds, medicaments thereof, and processes

Compounds of the formula ##STR1## wherein A, B, R.sub.1, X and Q are substituents of various types, and acid addition salts thereof. The compounds are useful as fungicides.

Acrylic acid heterocyclic amides, fungicidal compositions and use

Compounds of the formula ##STR1## wherein R.sub.1 is a substituted alkoxy group, or an optionally substituted mercapto or amino group,

2-(perhydro-1,4-diazino)-pyrimido[5,4-d]-pyrimidines and salts thereof

The invention relates to novel 2-phenyl-imidazoles of the formula ##STR1## and the tautomers and acid addition salts thereof, particularly the pharmacologically acceptable acid addition salts, which exhibit valuable pharmacological properties, particularly an effect on the contractility of the heart muscle. The compounds of Formula I may be prepared by methods conventionally used for similar compounds.

Novel 2-phenyl-imidazoles and pharmaceutical compositions containing same

The invention relates to new compounds of general formula ##STR1## wherein R.sub.1 represents an alkyl group,

8-alkylthio-2-piperazino-pyrimido[5,4-d]-pyrimidines

2-(Perhydro-1,4-diazino)-pyrimido(5,4-D)-pyrimidines, pharmaceutical

This invention relates to a compound of formula (I) ##STR1## wherein R.sub.1 and R.sub.2 are each independently hydrogen, C.sub.1 -C.sub.3 alkyl or C.sub.1 -C.sub.3 alkoxy; and R.sub.3 is a C.sub.7 -C.sub.9 aralkyl, the phenyl nucleus of which can be mono-, di-, or trisubstituted by halogen, C.sub.1 -C.sub.3 alkyl or C.sub.1 -C.sub.3 alkoxy, and nontoxic, pharmaceutically acceptable salts thereof. The compounds have useful antithrombic properties.

Quaternary 3,4-dihydro-isoquinolinium salts

The present invention relates to novel indolinones of the general formula ##STR1## wherein R represents an aryl group having from 6 to 10 carbon atoms, unsubstituted or mono- or disubstituted by alkyl groups having from 1 to 5 carbon atoms, hydroxyl groups, alkoxy groups having from 1 to 3 carbon atoms, or halogen atoms, whereby the substituents may be the same or different and whereby the phenyl nucleus of the aryl group may also be substituted by an amino group, a hydroxyl group, or an alkanoylamino group with altogether from 1 to 3 carbon atoms; an aryl group having from 6 to 10 carbon atoms, substituted by 3 or 4 alkyl groups having from 1 to 5 carbon atoms each; a phenyl group substituted by a phenyl, halogenphenyl, or cycloalkyl group with 5 to 7 carbon atoms; an aralkyl group having from 7 to 11 carbon atoms; or a pentamethylphenyl, pyridyl, or quinolyl group; m represents the number 0, 1, or 2; and n represents the number 2, 3, 4, 5, or 6.

Indolinones and pharmaceutical compositions containing same

Compounds of the formula ##STR1## wherein R.sub.1 is phenylalkylamino, alkylamino, dialkylamino, piperidino, morpholino, thiomorpholino or 1-oxido-thiomorpholino;

2-Piperazino-pteridines useful as antithrombotics and antimetastatics

Compounds of the formula ##STR1## wherein n is 0 or 1;

Antithrombotic sulfoximino carbostyrils

Antithrombotic use of 2-(perhydro-1,4-diazino)-pyrimido

Growing community of inventors

Biberach, Germany

Josef Nickl