Vysoka Skola Chemicko-technologicka V Praze

Vyzkumny Ustav Veterinarniho Lekarstvi, V.v.i.

Apigenex S.r.o.

Univerzita Palackeho V Olomouci

Ustav Organicke Chemie a Biochemie Av Cr, V.v.i.

Fyzikalni Ustav Av Cr, V.v.i.

Bioveta, A.s.

Josef Masek

Ladislav Droz

Jaroslav Turanek

Miroslav Ledvina

Irena Kratochvilova

Vladimir Vrzal

Libor Bittner

Roman Effenberg

Elissa Bartheldyova

Frantisek Hubatka

Milan Raska

Evzen Weigl

Jiri Nepereny

Michal Krupka

Jaroslav Turánek

New aminooxylipids of general formula I, wherein n=5-30 and X is polymethylene linker of the general formula II where n=2-10, or X is polyethylene glycol linker of the general formula III, wherein n=1-14 are provided. A method of preparation of the aminooxylipids of general formula I characterized in that the acylation of N-tert-butoxycarbonyl-polymethylenediamine {(CH)C&#x2014;O&#x2014;(C&#x2550;O)&#x2014;HN&#x2014;(CH)&#x2014;NH, n=2-13}, or N-tert-butoxycarbonyl-polyethyleglycoldiamine {(CH)C&#x2014;O&#x2014;(C&#x2550;O)&#x2014;HN&#x2014;(CH)&#x2014;[O&#x2014;(CH)]&#x2014;O&#x2014;(CH)NH, n=1-14} with in position C(2) symmetrically branched fatty acids of general formula IV, wherein n=5-30, in the presence of condensation reagent, or from acid of general formula IV derived acylchloride of general formula V wherein n=5-30, produces N-Boc-aminolipids of general formula VI, wherein n=5-30 a X is polymethylene linker of the general formula II or X is polyethylene glycol linker of the general formula III.

Aminooxylipids for the construction of self-assembling liposomal systems enabling their subsequent modification by biologically functional molecules

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Brno, Czechia

Josef Masek