Spofa, Spojene Podniky Pro Zdravotnickou Vyrobu

Spofa, Pharmaceutical Works

Josef Kral

Antonin Cerny

Bohumil Sevcik

Jiri Krepelka

Karel Rezabek

Miroslav Semonsky

Miroslav Seda

Marie Auskova

Milan Pesak

Josef Picha

Petr Bilek

Marie Krajcrova

Dagmar Picmausova

Maria Fruhaufova

Antonin Borovicka

Josef Stuchlik

Karel Rezabeck

Jana Strakova

This invention relates to a method for the treatment of endometritis (chronic and/or acute puerperal inflammations) in mammalian females comprising the administration of 1-(8-alpha-ergolinyl)-3,3-diethylurea derivatives of Formula I ##STR1## in which R.sup.1 represents an alkyl group containing 1 to 3 carbon atoms, R.sup.2 represents a hydrogen atom or an alkyl group containing 1 to 3 carbon atoms, and X represents a hydrogen atom or a double bond between the carbon atoms at positions 9 and 10. The compound according to Formula I, or a pharmaceutically acceptable acid addition salt thereof, is the physiologically active component of the therapeutic composition and method. The compound may be combined with a pharmaceutically acceptable diluent, vehicle, excipient, auxiliary, or carrier. The invention is particularly advantageous in veterinary medicine, when applied to the treatment of farm animals, such a cows.

Method for treatment of endometritis in mammalian females

Novel N.beta.-substituted 8-.beta.-aminoethylergolin-I derivatives and the acid addition salts thereof are disclosed. The described compositions are prepared by either reductive alkylation or selective reduction of corresponding derivatives containing carbonyl groups.

N.beta.-substituted 8-.beta.-aminoethylergolin-I derivatives and their

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Pohori-Chotoun, Czechoslovakia

Josef Kral