Basf Aktiengesellschaft

Basf Aktiengesellscaft

Josef Gries

Dieter Lenke

Albrecht Franke

Hans D Lehmann

Marco Thyes

Horst Koenig

Fritz-Frieder Frickel

Peter C Thieme

Manfred Raschack

Helmut Hagen

Hans-Juergen Teschendorf

Gerda Von Philipsborn

Claus D Mueller

Ludwig Friedrich

Phillip A Rossy

Gerd Steiner

Werner Seitz

Rainer Schlecker

Martin Traut

Liliane Unger

Hans Theobald

Walter-Wielant Wiersdorff

Klaus Ruebsamen

Karl-Heinz Geiss

Rolf Kretzschmar

Helmut Lietz

Verena Baldinger

Bernd Ostersehlt

Johannes Kunze

Wolfgang Rohr

Norbert Rieber

Hardo Siegel

Hans P Hofmann

Rudolf Kropp

Wolfgang Spiegler

Bernhard Schmied

Horst Kreiskott

August Amann

Harald Weifenbach

Hans-Guenther Hege

Hans J Treiber

Josef Mueller

Wolfgang Worstmann

Wolfram Frank

Franz Reicheneder

Ferdinand Dengel

Oskar Ehrmann

Hans-Dieter Lenke

Ulrich Ohnsorge

Albrecht Franke, Deceased

Hans-Joachim May

Frank Zimmermann

Rolf Lebkuecher

Josef Muller

Klaus Ruebsmen

Hans-Georg Kurbjuweit

Dirk Wuppermann

Claus D Muller

Hans-Gunther Hege

Hugo Kubinyi

Hans-Dieter Lehmann

Philip A Rossy

Dora I Reicheneder

Aminopropanol derivatives of the formula: ##STR1## where R.sup.1 and R.sup.2 are identical or different and are each hydrogen, alkyl, cycloalkyl, alkenyl, alkynyl or hydroxyalkyl, each of not more than 6 carbon atoms, alkoxyalkyl, alkylthioalkyl or dialkylaminoalkyl, each of not more than 9 carbon atoms in total, or phenylalkyl or phenoxyalkyl where the alkyl radical is of not more than 6 carbon atoms and the phenyl radical is unsubstituted or substituted by alkyl or alkoxy, each of not more than 3 carbon atoms, or R.sup.1 and R.sup.2, together with the nitrogen atom which links them, form a 5-membered to 7-membered saturated heterocyclic ring which can be substituted by one or two phenyl and/or hydroxyl radicals and can contain an oxygen or nitrogen atom, as a further heteroatom in the ring, and such an additional nitrogen atom can be substituted by alkyl of 1 to 3 carbon atoms or by phenyl, and -- .circle.Het is thien-2-yl, thien-3-yl, pyrid-2-yl, pyrid-3-yl, pyrid-4-yl, fur-2-yl, 1-alkylpyrr-2-yl, 1-alkylpyrr-3-yl or 1-alkylpyrazol-4-yl, alkyl being of 1 to 3 carbon atoms, and their physiologically tolerated addition salts with acids, and antiarrhythmic agents containing these compounds.

Aminopropanol derivatives of substituted 2-hydroxy-propiophenones, and

Benzofuran derivatives of the formula I ##STR1## where R.sup.1 to R.sup.5 and X have the meanings stated in the description, and therapeutic agents containing these derivatives.

Novel benzofuran derivatives and therapeutic agents containing them

Therapeutic agents containing enantiomers of propafenone, the preparation of the said agents and their use for certain groups of patients.

Therapeutic agents containing enantiomers of propafenone

Basically substituted phenylacetonitriles ##STR1## where R.sup.1 to R.sup.6 and n have the meanings stated in the description, and their preparation are described. The compounds are useful for the treatment of disorders.

Basically substituted phenylacetonitriles, their preparation and drugs

Novel 6-(acylaminaryl)-3(2H)-pyridazinones of the formula ##STR1## where R.sup.1, R.sup.2, R.sup.3, R.sup.4, A and B have the meanings given in the description, and their preparation are described. The compounds have thrombocyte aggregation-inhibiting activity.

6-(acylaminoaryl)-3(2H)-pyridazinone derivatives, and their use

1,4-disubstituted pyrazole derivatives of the formula I ##STR1## where R.sup.1 and R.sup.2 independently of one another are each hydrogen, lower alkyl or benzyl, or R.sup.1 and R.sup.2, together with the nitrogen atom to which they are bonded, may be a pyrrolidino, piperidino or morpholino radical, n is an integer from 2 to 5 and Z is a radical of the formula ##STR2## or QNR.sup.1 R.sup.2 where R.sup.1 and R.sup.2 have the same meanings as above, Q is ##STR3## A is CHR.sup.3 or NR.sup.3 in which R.sup.3 is CN, NO.sub.2, SO.sub.2 -aryl or SO.sub.2 -lower alkyl and m may be 0 or 1, and their pharmaceutically tolerated salts, processes for their preparation, pharmaceutical compositions containing the compounds of formula I, the use of such compositions and an intermediate of the formula III ##STR4## where R.sup.1, R.sup.2 and n have the same meanings as above, in the preparation of the compounds of the formula I. The compounds are useful to block histamine H.sub.2.sup.- receptors.

1,4-disubstituted pyrazole derivatives, compositions and use

Novel 1-phenyl-4(1H)-pyridazinone-imines of the formula (I) ##STR1## which are substituted at the imine nitrogen, and their addition salts with a physiologically tolerated acid, processes for their preparation, pharmaceutical formulations containing these compounds, and their use as drugs, in particular as antidepressants, antiparkinson drugs and antihypotonic agents.

Novel pyridazinone-imines and their physiologically tolerated addition

2-aryl-3,4-diazabicyclo[4.n.0]-alk-2-en-5-ones of the formula ##STR1## where m, n, R, R.sup.1, R.sup.2 and R.sup.3 have the stated meanings, are used for the treatment of cardiac insufficiency.

2-aryl-3,4-diazabicyclo(4.n.O)alk-2-en-5-ones for the preparation of an

Phenylacetaldehydes which are substituted by basic groups, of the formula ##STR1## where R.sup.1 to R.sup.8, m and n have the meanings stated in the description, and their preparation are described. The substances are useful for the treatment of disorders.

Phenylacetaldehydes substituted by basic groups, their preparation and

Novel pyrrol-1-ylphenyldihydropyridazinones of the formula ##STR1## their preparation and their use in the treatment of disorders.

Pyrrol-1-ylphenyldihydropyridazinones, their preparation and their use

Novel 6-(acylaminoaryl)-3(2H)-pyridazinones of the formula ##STR1## where R.sup.1, R.sup.2, R.sup.3, R.sup.4, A and B have the meanings given in the description, and their preparation are described and inhibiting thrombocyte aggregation and gastric secretion. The compounds are useful for treating disorders.

6-(acylaminoaryl)-3(2H)-pyridazinone derivatives and their use

Novel phenylpiperazinylpropane and -butane derivatives of hetarylphenols and hetarylanilines of the formula ##STR1## where R.sup.1 is hydrogen or alkyl of 1 to 4 carbon atoms, R.sup.2 is hydrogen, halogen, alkyl of 1 to 4 carbon atoms or alkoxy where alkyl is of 1 to 3 carbon atoms, the phenyl ring can be monosubstituted or disubstituted by R.sup.2, X is oxygen or an NH group, and the heterocyclic structure Het. is 1,3,4-oxadiazolyl, triazolyl, imidazolyl or pyrazolyl, and their physiologically tolerated addition salts with acids, processes for their preparation, and pharmaceutical formulations which contain these compounds and exhibit predominantly sedative, neuroleptic and hypotensive properties.

Phenylpiperazine derivatives of hetarylphenols and hetarylanilines,

Compounds of the general formula ##STR1## where R.sup.1, R.sup.2, R.sup.3, R.sup.4 and n have the meanings given in the description, are useful for treating cardiac disorders.

Aminopropanol derivatives of 1-(2-hydroxyphenyl)-3-phenylpropanols and

Novel aminopropanol derivatives of 2-hydroxy-.beta.-phenyl-propiophenones and their physiologically acceptable acid addition compounds, processes for their preparation and therapeutic agents which contain these derivatives and are useful as antiarrhythmic drugs.

Aminopropanol derivatives of 2-hydroxy-.beta.-phenyl-propiophenones,

6-Aryl-4,5-dihydro-3(2H)-pyridazinones of the formula ##STR1## where R is hydrogen, R.sup.1 is hydrogen or C.sub.1 -C.sub.3 -alkyl, or R and R.sup.1 together are methylene, R.sup.2 and R.sup.3 are identical or different and are each hydrogen or C.sub.1 -C.sub.6 -alkyl, and A is hydroxyl, C.sub.1 -C.sub.6 -alkoxy, C.sub.2 -C.sub.7 -acyloxy, a C.sub.2 -C.sub.7 -carbamic acid ester group, C.sub.1 -C.sub.6 -alkylsulfonyloxy, C.sub.1 -C.sub.6 -alkylmercapto, carboxyl, C.sub.2 -C.sub.7 -alkoxycarbonyl or nitrile, and their preparation are described. The substances are suitable for treating disorders.

6-Aryl-4,5-dihydro-3(2H)-pyridazinones, and their use as

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Wachenheim, Germany

Josef Gries