Novartis Ag

Sandoz Gmbh

Josef Gottfried Meingassner

Claus Ehrhardt

Peter Stutz

Erwin Paul Schreiner

Ulrich Hommel

Anton Stutz

Philipp Krastel

Maximilian Grassberger

Esther Schmitt

Brigitta-Maria Liechty

Stefanie Flohr

Rainer Albert

Wilfried Bauer

Nils Ostermann

Sylvain Cottens

Sompong Wattanasin

Joerg Kallen

Stefan Andreas Randl

Andreas Marzinzik

Rolf Baenteli

Gabriele Weitz-Schmidt

Berndt Oberhauser

Ulrich Hassiepen

Eberhard Schutze

Neil Stewart Ryder

Karl Welzenbach

Frederic Berst

J&ouml;rg Kallen

Gabriele Weitz Schmidt

Bernd Gerhartz

Ursula Bodendorf

Fran&ccedil;ois Nuninger

Klaus Thirring

Didier Roche

Hubert Mieth

Rudolf Czok

The present application relates to cyclic depsipeptides, or derivatives thereof, having the structure of formula (I), and uses thereof, e.g. as inhibitors of kallikrein 7 and human neutrophil elastase.

Cyclic depsipeptides

The present invention relates to the crystal structure of the serine protease kallikrein 7 and to the use of this crystal structure in drug discovery. The present invention also relates to compounds binding specifically to this active site of kallikrein 7.

Kallikrein 7 modulators

Pharmaceutically active diazepanes, e.g. useful for treating disorders or diseases mediated by LFA-1/ICAM-1, LFA-1/ICAM-2, LFA-1/ICAM-3 or LFA-1/JAM-1 interactions.

Diazepanes derivatives useful as IFA inhibitors

Lactones of Formula (I) which are pharmaceutically active in diseases associated with inflammation 

Antiinflammatory lactones

A pharmaceutical compound comprising a compound of formula I and a pharmaceutically acceptable 2-amino-1,3-propanediol beside one or more pharmaceutically acceptable excipient(s).

Macrolides containing pharmaceutical compositions

Mevinolin derivatives wherein the lactone ring is modified have interesting pharmaceutical properties, particularly in preventing or treating disorders or diseases mediated by LFA-1/ICAM-1 interactions.

Melvinolin derivatives

Substituted 2-oxo-1,4-diazacycloalkanes

Antifungal composition

The compounds of formula I, ##STR1## have been found to have excellent topical activity. They are thus indicated for use in the topical treatment of inflammatory and hyperpoliferative skin diseases and of cutaneous manifestations of immunologically-induced illnesses, such as psoriasis.

Use of 11,28-dioxa-4-azatricyclo[22.3.1.0.sup.4,9 ]octacos-18-ene

New use of 11,28-dioxa-4-azatricyclo[22.3.1.0.sup.4,9 ]octacos-18-ene derivatives and pharmaceutical compositions containing them The compounds of formula I, ##STR1## have been found to have excellent topical activity. They are thus indicated for use in the topical treatment of inflammatory and hyperpoliferative skin diseases and of cutaneous manifestations of immunologically-induced illnesses, such as psoriasis.

The invention provides a synergistic composition of a polyether antibiotic and a pleuromutilin derivative, which has an enhanced effect against coccidiosis in poultry. The composition may be prepared in the form of a premix concentrate and incorporated into commercial complete poultry feed. A method of treatment or prophylaxis of coccidiosis in poultry by co-administration of the components is also claimed.

Antibiotic compositions for treating coccidiosis

Growing community of inventors

Perchtoldsdorf, Austria

Josef Gottfried Meingassner