Merz Pharma Gmbh & Co Kgaa

Josef Friedrich

Michael Pfeil

Harold Victor Taylor

Karl-Heinz Eisele

Cornelia Brunn

Cornelia Brünn

Heiko Barg

Cornelia Bruenn

Wolfgang Liebetrau

Robert Voigts

Tim Stephen Ligman

Robert G Voigts

Harold V Taylor

Cornelia BRÜNN

The present invention relates to an antibody which specifically binds to unprocessed and/or partially processed neurotoxin polypeptide or an antibody which specifically binds an epitope consisting of a peptide having an amino acid sequence as shown in any one of SEQ ID NOs: 1 to 16 and to methods for the manufacture of such antibodies. Moreover, the present invention relates to a composition comprising processed neurotoxin polypeptide free of unprocessed or partially processed neurotoxin polypeptide and a method for manufacturing said neurotoxin polypeptide based on the antibodies of the invention. The present invention also relates to the use of the aforementioned antibody for separating processed neurotoxin polypeptides from unprocessed or partially processed neurotoxin polypeptides or for determining unprocessed or partially processed neurotoxin polypeptides. The present invention relates to a method for the manufacture of a medicament.

Antibody that specifically binds partially processed or unprocessed neurotoxin polypeptides

The invention relates to a method of preparing a composition, the composition comprising a crosslinked first polymer, optionally a second polymer, which may be crosslinked or non-crosslinked, and water, wherein the first and the second polymer are selected from a polysaccharide, comprising at least steps (i) to (iv):

Method of preparing a composition based on hyaluronic acid

Means and methods for manufacturing highly pure neurotoxin

The present invention pertains to the field of tools for ensuring manufacture of polypeptides and quality control. Specifically, it relates to a method for determining the amount of processed (active) neurotoxin polypeptides in a solution comprising processed neurotoxin polypeptides and partially processed or unprocessed neurotoxin polypeptides. The present invention further relates to a device for determining the amount of neurotoxin polypeptides and a kit adapted to carry out the method of the present invention.

Means and methods for the determination of the amount of neurotoxin polypeptide and of its catalytic and proteolytic activities

Growing community of inventors

Rauenberg, Germany

Josef Friedrich