The University of Chicago

Other

World Health Organization

Josef Fried

Sydney Archer

Carl Djerassi

Hyun K Kim

Richard P Blye

Gabriel Bialy

By Lucie Crabbe, Executor

William J Elliott

Egon Diczfalusy

Giuseppe Benagiano

Pierre Crabbe, Deceased

Pierre Crabbe

Egon R Diczfalusy

Long-acting androgenic compositions comprising C.sub.4 -C.sub.6 cycloalkyl carboxylic acids of testosterone and a pharmaceutically acceptable carrier medium. The ester can be dissolved in an acceptable oily medium or suspended in an aqueous medium in the form of micronised particles or in the form of milled particles.

Long-acting androgenic compounds and pharmaceutical compositions thereof

Esters of 17 .alpha.-ethynyl 19-nor-testosterone and 17 .alpha.-ethynyl-18-homo-19-nor-testosterone and the 3-oximes thereof having long-active contraceptive activity.

Esters of 17 .alpha.-ethynyl 19-nor-testosterone and 17

Prostaglandin and prostacyclin compounds which are fluorine substituted in any one or more of the following positions 4,4; 7,7; 10,10; and 5.

Chemical synthesis

Prostaglandin and prostacyclin compounds which are fluorine substituted in any one or more of the following positions, 4,4; 7,7; 10,10; and 5.

Certain fluorine substituted PGI.sub.2 compounds

This invention relates to compounds of the formulae ##STR1## wherein n is an integer from 2 to 5; M is H, acyl, lower alkyl, or lower alkoxy alkyl; Q is H or lower alkyl; R is alkyl, alkenyl or analkyl; A is H; Y is OH, acyloxy or alkoxy, and when taken together, Y and A is oxo (O.dbd.), and to novel intermediates therefore.

This invention relates to compounds of the formula: ##STR1## wherein A is hydrogen or fluorine;

Certain amides of prostacyclin and related compounds

This invention relates to pharmacologically active compounds of the formula: ##STR1## wherein Z is trans--CH.dbd.CH, C.tbd.C; or CH.sub.2 --CH.sub.2 ;

A practical stereocontrolled synthesis of a mixture containing a major amount of .alpha.-multistriatin and a minor amount of .gamma.-multistriatin in an overall yield of about 73% from cis-2-butene-1,4-diol is provided. .alpha.-Multistriatin is one of the three essential components of the aggregation pheromone of the European elm bark beetle.

Stereocontrolled synthesis of .alpha.-multistriatin

This invention relates to pharmacologically active compounds of the formula: ##STR1## wherein Z is trans-CH=CH, C.tbd.C; or CH.sub.2 -CH.sub.2 ;

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Chicago, IL, United States of America

Josef Fried