Lacer, S.a.

Lacer

Jose Repolles Moliner

Francisco Pubill Coy

Eduardo Salas Perez-Rasilla

Lydia Cabeza Llorente

Marisabel Mourelle Mancini

Juan Carlos Del Castillo Nieto

Cristina Negrie Rofes

Alicia Ferrer Siso

Marcelli Carbo Banus

Juan Antonio Cerda Riudavets

Marek W Radomski

Juan Martinez Bonnin

Anna Modolell Saladrigas

Carlos Malet Falco

In the present invention there are disclosed new derivatives of dianhydrohexite mononitrate corresponding to formula (I), tautomers, pharmaceutically acceptable salts, prodrugs and solvates thereof: as well as pharmaceutical compositions comprising these compounds and uses thereof.

Disulfide, sulfide, sulfoxide, and sulfone derivatives of cyclic sugars and uses thereof

The present invention relates to new 3-substituted 6-nitrooxy-hexahydrofuro[3,2-b]furane derivatives possessing a superior pharmacological activity in thrombosis and in coronary ischemia models.

Isosorbide nitrates

This invention relates to a new method for the stereospecific thiocarboxylation of organic compounds for the preparation of compounds according to formula (I): wherein a compound of formula (II): is reacted with a compound of formula (IIIa) or (IIIb): then treating the obtained product with a thiocarboxylic acid or a salt thereof, and subsequently carrying out a nitration reaction.

Stereospecific method for the preparation of dioxa-bicyclooctane compounds

In the present invention there are disclosed new derivatives of dianhydrohexite mononitrate corresponding to formula (I), tautomers, pharmaceutically acceptable salts, prodrugs and solvates thereof as well as pharmaceutical compositions comprising these compounds and uses thereof. 

Disulfide, sulfide, sulfoxide, and sulfone derivatives of cyclic sugars and uses

Novel derivatives of isosorbide mononitrate and its pharmaceutically acceptable salts, which have vasodilating activity with a reduced effect of tolerance, of the general formula (I)in which A and B independently represent any of the groups&#x2014;ONOand &#x2014;Z&#x2014;CO&#x2014;R, wherein Z is an oxygen atom or sulphur atom and R is an alkyl C-Cgroup, an aryl group or an aralkyl group, eventually substituted, or the groupin which Ris hydrogen, or an alkyl C-Cgroup, an aryl group or an aralkyl group, eventually substituted, with the proviso that one of A or B is always &#x2014;ONO, but never both of them at the same time, when Z is an sulphur atom R is an alkyl C-Cgroup, an aryl group or an aralkyl group, eventually substituted, and when Z is an oxygen atom R is the group

Derivatives of isosorbide mononitrate and its use as vasodilating agents with reduced tolerance

N-(.alpha.-substituted-pyridinyl)carbonyl dipeptide antihypertensive

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Barcelona, Spain

Jose Repolles Moliner