University of Saskatchewan

University of Saskacthewan

Kenya Agriculture and Livestock Research Organization (kalro)

International Liverstock Research Institute (ilri)

Jose Perez-Casal

Andrew A Potter

Michael Fontaine

Alexandra J Bolton

Xinming Song

Volker Gerdts

Joerg Jores

Reuben Soi

Yejun Wang

Hezron Wesonga

Jan Naessens

Immunogenic proteins comprisingsubsp.andsubsp.proteins, encoding polynucleotides, a method for producing said proteins, and use of compositions to preventsubsp.infections are disclosed.

vaccines and uses thereof

The GapC plasmin binding protein genes of(),(),(),(), and() are described, as well as the recombinant production of the GapC proteins therefrom. Also described is the use of the GapC proteins from those species in vaccine compositions to prevent or treat bacterial infections in general, and mastitis in particular.

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The CAMP factor gene of() is described, as well as the recombinant production of CAMP factor therefrom. Also disclosed are chimeric CAMP factor constructs, including CAMP factor epitopes from more than one bacterial species. The CAMP factors and chimeras including the same can be used in immunogenic compositions for the prevention and treatment of bacterial infections.

The recombinant production of Gap4, a chimeric GapC plasmin binding protein comprising the entire amino acid sequence of theGapC protein in addition to unique amino acid sequences from theandGapC proteins, is described. Also described is the use of Gap4 chimeric GapC protein in vaccine compositions to prevent or treat streptococcal infections in general and mastitis in particular.

CAMP factor of Streptococcus uberis

The recombinant production of Gap4, a chimeric GapC plasmin binding protein comprising the entire amino acid sequence of theGapC protein in addition to unique amino acid sequences from theandGapC proteins, is described. Also described is the use of Gap4 chimeric GapC protein in vaccine compositions to prevent or treatinfections in general and mastitis in particular.

Immunization of dairy cattle with chimeric GapC protein against streptococcus infection

Immunization of dairy cattle with GapC protein against Streptococcus infection

The GapC plasmin binding protein genes of ( ), ( ), ( ), ( ), and ( ) are described, as well as the recombinant production of the GapC proteins therefrom. Also described is the use of the GapC proteins from those species in vaccine compositions to prevent or treat bacterial infections in general, and mastitis in particular.

The recombinant production of Gap4, a chimeric GapC plasmin binding protein comprising the entire amino acid sequence of the GapC protein in addition to unique amino acid sequences from the and GapC proteins, is described. Also described is the use of Gap4 chimeric GapC protein in vaccine compositions to prevent or treat streptococcal infections in general and mastitis in particular.

Growing community of inventors

Saskatoon, Canada

Jose Perez-Casal