Laboratorios Almirall, S.a.

Fordonal, S.a.

Anphar, S.a.

Jose P Soto

Jacinto M Mauri

Armando V Noverola

Robert G Spickett

Armando Vega-Noverola

Jose Boix-Igleasias

Carles P Duran

Dolors F Forner

R G Spickett

A compound of formula (I) ##STR1## wherein R.sup.1 and R.sup.2 each represents a hydrogen atom or an alkyl group, Z represents a ring selected from: ##STR2## in which n represents 4, 5 or 6; ##STR3## in which R.sup.3 represents hydrogen or an alkyl group and R.sup.4 represents an alkyl, methoxy benzyl or R.sup.5 NHCO group, R.sup.5 being an alkyl group; and ##STR4## in which R.sup.6 represents an alkyl group. and pharmaceutically acceptable salts thereof are useful in the treatment of migraine and other conditions. They are prepares by decarboxylation of the corresponding indolyl 2-carboxylic acid.

Indole derivatives

This invention relates to new therapeutically useful piperidine derivatives and salts thereof. The invention also relates to processes for their preparation and pharmaceutical compositions containing them.

Piperidine derivatives

The invention relates to aromatic amides N-substituted by heterocyclic groups. More particularly, the invention relates to substituted benzoic acid amides of 1-arylalkylamino or aminoalkyl-N-heterocyclic rings and to pharmaceutical compositions thereof, which have the ability to antagonize the effects of dopamine or dopaminergic agents of endogenous or exogenous origin and which may be used for the treatment of nausea and vomiting resulting from gastrointestinal disorders, congestive heart failure, post operative conditions, etc., other gastrointestinal disorders such as dyspepsia, flatulence, bile regurgitations, hiatus hernia, peptic ulcer, reflux aerophagitis, gastritis, duodenitis, and cholethiasis, and a variety of conditions affecting the central nervous system such as acute and chronic psychoses, maniacal psychosis, schizophrenias, serious disturbances of behavior and non-melancholic depressive state and migraine.

Aromatic amides of heterocyclic compounds and therapeutic compositions

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Barcelona, Spain

Jose P Soto