Laboratorios Made, S.a.

Basf Aktiengesellschaft

Abbott Gmbh & Co Kg

Jose Maria Castellano Berlanga

Miguel Fernandez Brana

Marina Moran Moset

Cristobal Martinez Roldan

Lee Daniel Arnold

David J Calderwood

Paul Rafferty

Cynthia A Romerdahl

Gerhard Keilhauer

Xiao-Dong Qian

Peter Bousquet

Isabel Fernandez

Maria Luz Lopez Rodriguez

Maria Jesus Perez De Vega

Christobal Martinez Roldan

Jose L Soto Camara

Chemical compounds having structural formula I and physiologically acceptable salts thereof, are inhibitors of serine/threonine and tyrosine kinase activity. Several of the tyrosine kinases, whose activity is inhibited by these chemical compounds, are involved in angiogenic processes. Thus, these chemical compounds can ameliorate disease states where angiogenesis or endothelial cell hyperproliferation is a factor. These compounds can be used to treat cancer and hyperproliferative disorders.

2-pyrazolin-5-ones

Disclosed herein are compounds pharmaceutical compositions containing same of the formula

Bis-naphthalimides for the treatment of cancer

1,2-diacylamino-1,2-di(4-pyridil)ethanes of general formula: ##STR1## where R is a saturated or unsaturated alkyl group, a homocyclic or heterocyclic aromatic ring, with or without substituents, or a saturated or unsaturated cycloalkyl. Said compounds are useful as analgesic. A process for preparing such products is also described.

1,2-Diacylamino-1,2-di(4-pyridyl)ethanes and process for producing

The invention relates to the compound 5-Hydroxytryptophan Glutamate, having anti-depressive action.

Compounds 5-hydroxytryptophan glutamate and its derivatives

Compounds having the formula ##EQU1## wherein R is 2-picolyl, 3-picolyl or 4-picolyl. The compounds are prepared by reacting dipropylacetic acid, or the corresponding chloride or anhydride, with 2-picolylamine, 3-picolylamine or 4-picolylamine. The compounds possess anti-convulsant and barbiturate potentiation properties.

Method for industrial production of N-substituted dipropylacetamides

Growing community of inventors

Madrid, Spain

Jose Maria Castellano Berlanga