Almirall Prodesfarma S.a.

Laboratorios Almirall, S.a.

Fordonal, S.a.

José Manuel Prieto Soto

Bernat Vidal Juan

Jordi Gracia Ferrer

Armando Vega Noverola

Carlos Puig Duran

Silvia Fonquerna Pou

Jacinto M Mauri

Robert G Spickett

Armando Vega-Noverola

Cristina Esteve Trias

Aranzazu Cardus Figueras

Joan Feixas Gras

Fernando P Noguera

Luis Miguel Pages Santacana

This invention is directed to selective antagonists of Hhistamine receptors having the general formula (I); to processes for their preparation; to pharmaceutical compositions comprising them; and to their use in therapy. 

Azaindolylpiperidine derivatives as antihistaminic and antiallergic agents

This invention relates to new therapeutically useful 8-(disubstituted)phenyl-6,9-dihydro-5H-pyrrolo[2,3-e][1,2,4]triazolo[4,3-c]pyrimidine-5-one and 8-phenyl-6,9-dihydro-5H-pyrrolo[3,2-e][1,2,4]triazolo[4,3-c]pyrimidine-5-one derivatives of formula (I): wherein: &#x2014;X&#x2014;C&#x2014;Y&#x2014; represents (a) or (b) to processes and intermediates for their preparation, to pharmaceutical compositions containing them and to their medical uses as potent and selective inhibitors of phosphodiesterase 5 (PDE 5).

Pyrrolotriazolopyrimidinone derivatives

8-phenyl-6,9-dihydro-[1,2,4]triazolo[3,4-i]purin-5-one derivatives of formula (I):or a pharmaceutically acceptable salt thereof processes for their preparation, pharmaceutical compositions containing them and their use as PDE 5 inhibitors.

8-phenyl-6,9-dihydro-[1,2,4]triazolo[3,4-i]purin-5-one derivatives

The invention relates to new 6-phenylpyrrolopyrimidine derivatives of formula (I):wherein: &#x2014;X&#x2014;C&#x2014;Y&#x2014; represents

6-phenylpyrrolopyrimidinedione derivatives

Compounds of the general formula: ##STR1## wherein the various substituents are defined hereinbelow have pharmacological properties rendering them useful as antiemetic agents with reduced undesirable side-effects. Various methods are described for their preparation involving formation of the amide link, etherification of the 2-hydroxy derivative, introducing the R.sup.5 CH.sub.2 group on the N-unsubstituted azabicyclooctane or nonane or, for 4-amino compounds by hydrolysing a 4-acylamino derivative.

Antiemetic N-substituted benzamides

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Barcelona, Spain

José Manuel Prieto Soto