Universitá Degli Studi Di Padova

Fondazione Istituto Italiano Di Tecnologia

Alma Mater Studiorum-Universitá Di Bologna

Fondazione Istituto Italiano Di Technologia

Jose Manuel Arencibia Jimenez

Marco De Vivo

Claudia Sissi

Jose Antonio Ortega Martinez

Jose Antonio Ortego Martinez

Anna Minarini

The invention relates to a class of 5-carboxamide-2-thiobarbituric acid derivatives which inhibits human type II topoisomerase (topoII) enzyme and to use thereof as medicaments especially for blocking the proliferation of cancer cells and treating cancer. The invention also provides a method for the manufacture of the 5-carboxamide-2-thiobarbituric acid derivatives.

5-carboxamide-2-thiobarbituric acids and use thereof as medicaments

The present invention concerns 4-amino-2-pyrido-bicyclic pyrimidines of Formula (I) that function as type II topoisomerase inhibitors and their use thereof as medicaments especially in the treatment of cancer. The invention also provides a method for the manufacture of 4-amino-2-pyrido bicyclic pyrimidines of Formula (I).

4-amino-2-pyrido-bicyclic pyrimidines and use thereof as topoisomerase II inhibitors

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Genoa, Italy

Jose Manuel Arencibia Jimenez