Merck + Co., Inc.

Jose M Vega

Feng Xu

Paul J Reider

Richard D Tillyer

Mandana Asgharnejad

Edward J J Grabowski

The instant invention provides methods and pharmaceutical compositions for inhibiting HMG-CoA reductase, as well as for treating and/or reducing the risk for diseases and conditions affected by inhibition of HMG-CoA reductase, comprising orally administering a therapeutically effective amount of a compound selected from a dihydroxy open acid statin and a pharmaceutically acceptable salt or ester thereof in a delayed-release pharmaceutical dosage form to a patient in need of such treatment wherein substantial release of the compound from the dosage form is delayed until after passage of the dosage form through the stomach.

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Trappe, PA, United States of America

Jose M Vega